RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism
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Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalphaHaploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neuronsDynamics and diverse functions of nuclear pore complex proteinsThe RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexesThe orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival.Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.Chimeric Genes in Deletions and Duplications Associated with Intellectual DisabilityDeficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromesSelective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa.A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa.Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection.Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viabilityBiology and biophysics of the nuclear pore complex and its componentsRanbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe.Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide.Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.Protein sumoylation in brain development, neuronal morphology and spinogenesis.SUMO rules: regulatory concepts and their implication in neurologic functions.SUMO conjugation - a mechanistic view.Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin.The roles of the nuclear pore complex in cellular dysfunction, aging and disease.Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma.Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939.Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2.Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.The RanBP2/RanGAP1*SUMO1/Ubc9 complex: a multisubunit E3 ligase at the intersection of sumoylation and the RanGTPase cycle.Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis.Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I
P2860
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P248
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P2860
RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@ast
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en-gb
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@nl
type
label
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@ast
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en-gb
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@nl
altLabel
RanBP2 Modulates Cox11 and Hex ...... Deficits in Glucose Metabolism
@en
prefLabel
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@ast
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en-gb
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@nl
P2093
P2860
P921
P3181
P1433
P1476
RanBP2 modulates Cox11 and hex ...... deficits in glucose metabolism
@en
P2093
Azamat Aslanukov
Cheryl B Bock
John Oswald
Mallikarjuna Guruju
Paul A Sieving
Reshma Bhowmick
Ronald A Bush
Xinrong Lu
P2860
P3181
P356
10.1371/JOURNAL.PGEN.0020177
P407
P577
2006-10-01T00:00:00Z