Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 - Test2 - elhamkhani - TriplyDB

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

http://www.wikidata.org/entity/Q24290518

about

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism The septins Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death Parkin ubiquitinates and promotes the degradation of RanBP2 Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP Parkin mono-ubiquitinates Bcl-2 and regulates autophagy Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation Synaptic vesicle trafficking and Parkinson's disease Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11 Autoregulation of Parkin activity through its ubiquitin-like domain p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1 The role of oxidative stress in Parkinson's disease Parkin accumulation in aggresomes due to proteasome impairment Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals How does parkin ligate ubiquitin to Parkinson's disease?The continuing challenges of leprosy Analysis of mammalian septin expression in human malignant brain tumors Genetics of Parkinson disease The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1 Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis Molecules that cause or prevent Parkinson's disease Parkin counteracts symptoms in a Drosophila model of Parkinson's disease.Evolutionary and functional relationships within the DJ1 superfamily Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

http://www.wikidata.org/entity/Q24290518

description

2000 nî lūn-bûn

@nan

2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

@ast

Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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type

label

Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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prefLabel

Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Parkin functions as an E2-depe ...... e-associated protein, CDCrel-1

@en

P2093

H Huang

http://www.w3.org/2001/XMLSchema#string

J Gao

http://www.w3.org/2001/XMLSchema#string

K K Chung

http://www.w3.org/2001/XMLSchema#string

T M Dawson

http://www.w3.org/2001/XMLSchema#string

V L Dawson

http://www.w3.org/2001/XMLSchema#string

Y Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

The septin CDCrel-1 binds syntaxin and inhibits exocytosis

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene

cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Identification of septins in neurofibrillary tangles in Alzheimer's disease

P304

13354-9

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P31

scholarly article

P3181

987693

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P356

10.1073/PNAS.240347797

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P407

P433

24

http://www.w3.org/2001/XMLSchema#string

P478

97

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P577

2000-11-21T00:00:00Z

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P5875

24457814

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P698

11078524

http://www.w3.org/2001/XMLSchema#string

P921

ubiquitin-protein transferase activity

P932

27228

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