St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor - Test2 - elhamkhani - TriplyDB

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

http://www.wikidata.org/entity/Q24681068

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics Modulation of xenobiotic receptors by steroids Targeting xenobiotic receptors PXR and CAR for metabolic diseases Polyherbal formulation: Concept of ayurveda In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes Vitamin E in human health and disease Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha Biochemical Mechanisms for Geographical Adaptations to Novel Toxin Exposures in Butterflyfish Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions Pregnane X receptor and natural products: beyond drug-drug interactions The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.Summary of information on human CYP enzymes: human P450 metabolism data.Pharmacokinetic interactions of drugs with St John's wort.Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of Tanzanian plant extracts traditionally used for treatment of fungal infections.Clinically relevant safety issues associated with St. John's wort product labels.Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor Improving the oral bioavailability of beneficial polyphenols through designed synergies.St. John's Wort Has Metabolically Favorable Effects on Adipocytes In Vivo.The best of both approaches. The role of science in complementary and alternative medicine Effect of Red Clover on CYP Expression: An Investigation of Herb-Drug Interaction at Molecular Level.Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology.St. John's Wort enhances the synaptic activity of the nucleus of the solitary tract Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Regulation of xenobiotic metabolism by orphan nuclear receptors.P-Glycoprotein- and cytochrome P-450-mediated herbal drug interactions.St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.Orphan nuclear receptors: the exotics of xenobiotics.Herbal modulation of P-glycoprotein.The Chinese herbal medicine Sophora flavescens activates pregnane X receptor Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent.Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism.

P2860

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P2860

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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2000 nî lūn-bûn

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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2000年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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B Goodwin

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C J Serabjit-Singh

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G B Wisely

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J L Collins

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L B Moore

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S A Kliewer

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T M Willson

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P2860

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

St John's wort for depression--an overview and meta-analysis of randomised clinical trials

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

Herb-drug interactions.

Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.).

St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy.

Hyperforin as a possible antidepressant component of hypericum extracts.

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7500-2

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scholarly article

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1908843

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10.1073/PNAS.130155097

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13

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97

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10852961

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