Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha
about
DNA synthesis at individual replication forks requires the essential initiation factor Cdc45pA new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extractsLocalisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplificationThe Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase.Human Cdc45 is a proliferation-associated antigen.The mini-chromosome maintenance (Mcm) complexes interact with DNA polymerase α-primase and stimulate its ability to synthesize RNA primersEukaryotic MCM proteins: beyond replication initiation.Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.Activation of a human chromosomal replication origin by protein tethering.Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication.Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survivalSafeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast.Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.Cdc45 associates with the pre-replicative complex at the originPrimer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p.Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast.
P2860
Q24599663-CA838DAE-4590-4934-8AB7-B41F5A936BFBQ24671674-C78261F6-0024-4D5E-B54D-C0BC424D618BQ28140268-49365040-01DE-40C3-B226-F68D6591E900Q33786843-8465E2D6-DCF5-49B6-BB29-1DA68607CA70Q34557750-F93F8655-DA07-48C6-A378-5B7A14B57182Q34638233-7937C225-2628-4FF0-A810-E22BF2C328E4Q34645501-38098CA3-9F65-494E-8BC3-E0E1F4C203CCQ34973846-F2359EF6-3FD3-451E-B2DF-B33625D7A046Q35684975-A1226569-1D6E-4131-8F97-2F76F7B67285Q36891684-D317DCF2-B574-403E-BF98-38D3A6A0F648Q37012985-0669E46D-0A34-4F7F-A131-ADDD2548FE8CQ37218536-EF31033F-7932-420C-A33A-F28A0E2D7273Q37349653-2670F863-E8F0-4EAD-8324-0C9A35659DF1Q37563571-0F96A607-0CF7-44EC-A634-E522FDC0DD67Q37936675-D52D066B-56AD-4A63-B6B6-571347199852Q39586396-8B45BA9B-F998-4D61-A601-118B44DE7A99Q40489051-1EBA2826-A363-4D36-A47F-B137A64F58B7Q50286037-29D64144-70F4-49ED-898A-E4FA2E8D506BQ50335524-4C0C997B-EB17-4A8E-9B1E-7FEF64EAE381Q52135560-ACBD406C-713C-4F1D-9284-0C5550F3B8EB
P2860
Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@ast
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en-gb
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@nl
type
label
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@ast
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en-gb
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@nl
prefLabel
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@ast
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en-gb
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@nl
P2093
P2860
P1433
P1476
Human CDC45 protein binds to m ...... ubunit of DNA polymerase alpha
@en
P2093
P2860
P304
P356
10.1046/J.1432-1327.1999.00791.X
P407
P577
1999-11-01T00:00:00Z