Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
about
ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseasesHuman CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alphaThe dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich regionPR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cellsThe human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phaseThe regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsCdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingThe human homolog of Saccharomyces cerevisiae CDC45Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisPhosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationRegulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidizationIdentification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replicationStability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleHIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progressionChanges in association of the Xenopus origin recognition complex with chromatin on licensing of replication originsCell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationReplication licensing and cancer--a fatal entanglement?Preventing re-replication of chromosomal DNA.Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6Localization of proteins bound to a replication origin of human DNA along the cell cycleCdc7-Dbf4 and the human S checkpoint response to UVCHA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replicationAn essential role for Orc6 in DNA replication through maintenance of pre-replicative complexesSelective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammalsNuclear annexin II negatively regulates growth of LNCaP cells and substitution of ser 11 and 25 to glu prevents nucleo-cytoplasmic shuttling of annexin II.Functions of Ubiquitin and SUMO in DNA Replication and Replication StressRegulation of Unperturbed DNA Replication by UbiquitylationGenomic instability in cancer.Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association.G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityInhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteinsThe SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradationAssembly of the human origin recognition complexCell cycle-dependent proteolysis and phosphorylation of human Mcm10Cyclin-dependent kinases prevent DNA re-replication through multiple mechanismsNuclear organization of DNA replication initiation proteins in mammalian cells
P2860
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P2860
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@ast
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en-gb
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@nl
type
label
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@ast
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en-gb
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@nl
prefLabel
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@ast
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en-gb
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@nl
P2093
P2860
P3181
P356
P1476
Human CDC6/Cdc18 associates wi ...... ucleus at the onset of S phase
@en
P2093
J D Parvin
M Hendricks
S J Lawlis
P2860
P304
P3181
P356
10.1128/MCB.18.5.2758
P407
P577
1998-05-01T00:00:00Z