An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.
about
The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6pHuman CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alphaThe human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phaseThe regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsHuman CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phaseA human protein related to yeast Cdc6pHuman and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localizationCell cycle-regulated expression of mammalian CDC6 is dependent on E2F.Disruption of mechanisms that prevent rereplication triggers a DNA damage responseThe Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeastCdc6 protein causes premature entry into S phase in a mammalian cell-free system.Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationRegulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidizationIdentification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding propertiesStability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleInvolvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatinHuman geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosisDNA synthesis at individual replication forks requires the essential initiation factor Cdc45pPrevention of DNA re-replication in eukaryotic cellsATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replicationA tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studiesCdc6 is regulated by E2F and is essential for DNA replication in mammalian cellsIdentification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteinsMechanisms for initiating cellular DNA replicationThe Hect domain E3 ligase Tom1 and the F-box protein Dia2 control Cdc6 degradation in G1 phaseThe essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association.Swi5 controls a novel wave of cyclin synthesis in late mitosis.Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress.Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae.Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.Cell cycle dependent topological changes of chromosomal replication origins in Saccharomyces cerevisiae.In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.Cdk phosphorylation of a nucleoporin controls localization of active genes through the cell cycle.Architecture of the yeast origin recognition complex bound to origins of DNA replication.Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
P2860
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P2860
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@ast
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@en
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@nl
type
label
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@ast
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@en
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@nl
prefLabel
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@ast
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@en
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@nl
P2093
P3181
P356
P1433
P1476
An essential role for the Cdc6 ...... ve complexes of budding yeast.
@en
P2093
P2888
P3181
P356
10.1038/379180A0
P407
P577
1996-01-11T00:00:00Z
P6179
1035350994