about
In vitro evolution goes deepWeak selection and protein evolutionProtein stability: computation, sequence statistics, and new experimental methodsElucidating the molecular architecture of adaptation via evolve and resequence experimentsFrom systems to structure: bridging networks and mechanismSort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relationsOptimization of affinity, specificity and function of designed influenza inhibitors using deep sequencingSystematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionGenomic investigations of evolutionary dynamics and epistasis in microbial evolution experimentsCan the experimental evolution programme help us elucidate the genetic basis of adaptation in nature?Applications of comparative evolution to human disease geneticsReverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target InteractionsRapid bursts and slow declines: on the possible evolutionary trajectories of enzymesSpaces of the possible: universal Darwinism and the wall between technological and biological innovationA penalized-likelihood method to estimate the distribution of selection coefficients from phylogenetic dataEvolution of increased complexity in a molecular machineThe evolution of protein structures and structural ensembles under functional constraint.Viewing protein fitness landscapes through a next-gen lens.A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing.Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeastEffects of new mutations on fitness: insights from models and data.Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis DataFisher's geometrical model emerges as a property of complex integrated phenotypic networksInference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.Inferring fitness landscapes by regression produces biased estimates of epistasis.Evolution of two-component signal transduction systemsEnrich: software for analysis of protein function by enrichment and depletion of variants.Quantifying selection acting on a complex trait using allele frequency time series data.Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.Fitness analyses of all possible point mutations for regions of genes in yeast.Simulated evolution of protein-protein interaction networks with realistic topology.Evolutionary biochemistry: revealing the historical and physical causes of protein properties.Advances in quantitative trait analysis in yeast.Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution.Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain.A systematic survey of an intragenic epistatic landscape.Latent effects of Hsp90 mutants revealed at reduced expression levels.Properties of selected mutations and genotypic landscapes under Fisher's geometric model.Massively parallel single-amino-acid mutagenesisMeasuring the activity of protein variants on a large scale using deep mutational scanning.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Experimental illumination of a fitness landscape
@ast
Experimental illumination of a fitness landscape
@en
Experimental illumination of a fitness landscape
@en-gb
Experimental illumination of a fitness landscape
@nl
type
label
Experimental illumination of a fitness landscape
@ast
Experimental illumination of a fitness landscape
@en
Experimental illumination of a fitness landscape
@en-gb
Experimental illumination of a fitness landscape
@nl
prefLabel
Experimental illumination of a fitness landscape
@ast
Experimental illumination of a fitness landscape
@en
Experimental illumination of a fitness landscape
@en-gb
Experimental illumination of a fitness landscape
@nl
P2860
P3181
P356
P1476
Experimental illumination of a fitness landscape
@en
P2093
Ryan T Hietpas
P2860
P304
P3181
P356
10.1073/PNAS.1016024108
P407
P577
2011-04-04T00:00:00Z