Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
about
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionEstrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteriesThe RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membraneRadixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferationEpac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cellExchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neuronsThe M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytesPI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.Mechanisms of action of glucagon-like peptide 1 in the pancreasThe Dictyostelium genome encodes numerous RasGEFs with multiple biological rolesRole of EPAC in cAMP-Mediated Actions in Adrenocortical CellsRegulation of small GTPases by GEFs, GAPs, and GDIsRole of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiologyStructural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1aStructural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMPcAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Cell physiology of cAMP sensor Epac.Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinaseRap1 GTPases: an emerging role in the cardiovasculatureCritical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretionRap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferationDifferential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retinaExchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channelsPiccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosisPDE5 is converted to an activated state upon cGMP binding to the GAF A domainExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsActivation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cellsDissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway.Direct spatial control of Epac1 by cyclic AMP.Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responsesG-protein Golfalpha (GNAL) is expressed in the vestibular end organs and primary afferent neurons of Rattus norvegicus.Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog.Epac mediates PACAP-dependent long-term depression in the hippocampus.PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes.A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer.Signaling in sperm: toward a molecular understanding of the acquisition of sperm motility in the mouse epididymis.
P2860
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P2860
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
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2000 nî lūn-bûn
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@ast
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en-gb
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@nl
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label
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@ast
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en-gb
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@nl
prefLabel
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@ast
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en-gb
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@nl
P2093
P2860
P3181
P356
P1476
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
@en
P2093
Wittinghofer A
de Rooij J
van Triest M
P2860
P304
20829-20836
P3181
P356
10.1074/JBC.M001113200
P407
P577
2000-07-01T00:00:00Z