The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
about
A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayProtein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathwayThe Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylationMixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathwaysAutoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular processRegulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress responseDiscovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascadesAdjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disordersMixed-lineage kinase control of JNK and p38 MAPK pathways.Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in micePAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationPlant Raf-like kinase integrates abscisic acid and hyperosmotic stress signaling upstream of SNF1-related protein kinase2.Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLKThe interferon signaling network and transcription factor C/EBP-betaJNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinaseDependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinaseInvolvement of mixed lineage kinase 3 in cancer.TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT.Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015).Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop.Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.The Arabidopsis Mitogen-Activated Protein Kinase Kinase Kinase 20 (MKKK20) Acts Upstream of MKK3 and MPK18 in Two Separate Signaling Pathways Involved in Root Microtubule Functions.Dimerization in protein kinase signaling.Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield.Fasudil hydrochloride protects neurons in rat hippocampal CA1 region through inhibiting GluR6-MLK3-JNKs signal pathway.Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3
P2860
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P2860
The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@ast
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en-gb
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@nl
type
label
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@ast
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en-gb
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@nl
prefLabel
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@ast
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en-gb
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@nl
P2860
P921
P3181
P356
P1476
The kinase activation loop is ...... nitor kinase 1 phosphorylation
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.M004092200
P407
P577
2001-01-19T00:00:00Z