Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
about
Genome analysis reveals interplay between 5'UTR introns and nuclear mRNA export for secretory and mitochondrial genesSelective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumorsCharacterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein coreA novel mode of RBD-protein recognition in the Y14-Mago complexBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayeIF4G is required for the pioneer round of translation in mammalian cellseIF4A3 is a novel component of the exon junction complexIsolation and characterization of post-splicing lariat-intron complexesInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysRegulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translationIdentification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decayA competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decayUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cellsMicroRNA maturation: stepwise processing and subcellular localization.Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardationSplicing enhances translation in mammalian cells: an additional function of the exon junction complexNuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathwaysStructure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processingIntegration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cellsNonsense-mediated mRNA decay: inter-individual variability and human diseaseCrystal structure of the Drosophila Mago nashi-Y14 complexInsights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complexStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastCap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast.Nonsense-mediated mRNA decay in humans at a glanceNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryA simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complexAn evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formationEvidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humansRNA helicase A is necessary for translation of selected messenger RNAs.
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P2860
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
description
2001 nî lūn-bûn
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2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
@en-gb
Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
@ast
Role of the nonsense-mediated ...... ent exon-exon junction complex
@en
Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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Role of the nonsense-mediated ...... ent exon-exon junction complex
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10.1126/SCIENCE.1062829
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2001-09-07T00:00:00Z