Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways
about
An unappreciated role for RNA surveillanceDe novo ORFs in Drosophila are important to organismal fitness and evolved rapidly from previously non-coding sequencesBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decaySMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decaySMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayA competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decayA crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.Structural characterization of the Rous sarcoma virus RNA stability elementStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexSplicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex componentsNonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knifePre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genesA GFP-based reporter system to monitor nonsense-mediated mRNA decayMechanism and regulation of the nonsense-mediated decay pathwayProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsStructural and functional insights into the human Upf1 helicase coreMolecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complexThe Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITSSaccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complexNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryTelomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome endsProtein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseFunctions of the nonsense-mediated mRNA decay pathway in Drosophila developmentHow and where are nonsense mRNAs degraded in mammalian cells?The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasisA program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexesWhere do introns come from?Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansGenome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila.Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3Expression of the eRF1 translation termination factor is controlled by an autoregulatory circuit involving readthrough and nonsense-mediated decay in plants.VHL frameshift mutation as target of nonsense-mediated mRNA decay in Drosophila melanogaster and human HEK293 cell line.
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P2860
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways
description
2003 nî lūn-bûn
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2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2003 թվականի օգոստոսին հրատարակված գիտական հոդված
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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name
Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
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Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
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Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
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type
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Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
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Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
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Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
@nl
prefLabel
Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
@ast
Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
@en
Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
@nl
P2860
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P3181
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Nonsense-mediated mRNA decay i ...... e yeast and mammalian pathways
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P2093
David Gatfield
P2860
P304
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10.1093/EMBOJ/CDG371
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P577
2003-08-01T00:00:00Z