Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex
about
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayA noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defectsDEAD-box proteins as RNA helicases and chaperonesNonsense-mediated mRNA decay: novel mechanistic insights and biological impactStructural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactionsCrystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domainStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryThe RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNAHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Multifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes.Disorders with similar clinical phenotypes reveal underlying genetic interaction: SATB2 acts as an activator of the UPF3B gene.Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.A highly conserved region essential for NMD in the Upf2 N-terminal domainFull UPF3B function is critical for neuronal differentiation of neural stem cells.Perispeckles are major assembly sites for the exon junction core complex.A New Mutation, hap1-2, Reveals a C Terminal Domain Function in AtMago Protein and Its Biological Effects in Male Gametophyte Development in Arabidopsis thaliana.Intranuclear binding in space and time of exon junction complex and NXF1 to premRNPs/mRNPs in vivo.Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis.Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation.Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complexThe DEAD-box helicase eIF4A: paradigm or the odd one out?The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathwaysAn aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase.NMD: a multifaceted response to premature translational termination.Assembly, disassembly and recycling: the dynamics of exon junction complexes.Regulation of nonsense-mediated mRNA decay.When core competence is not enough: functional interplay of the DEAD-box helicase core with ancillary domains and auxiliary factors in RNA binding and unwinding.mRNA metabolism and neuronal disease.Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Physiological and pathophysiological role of nonsense-mediated mRNA decay.The exon junction complex: a lifelong guardian of mRNA fate.Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
P2860
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P2860
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@ast
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@en
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@nl
type
label
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@ast
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@en
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@nl
prefLabel
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@ast
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@en
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@nl
P2093
P2860
P50
P3181
P356
P1476
Insights into the recruitment ...... re of a core EJC-UPF3b complex
@en
P2093
Fulvia Bono
Gretel Buchwald
Judith Ebert
Uma Jayachandran
P2860
P304
P3181
P356
10.1073/PNAS.1000993107
P407
P577
2010-06-01T00:00:00Z