The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity
about
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesFunctional proteomics mapping of a human signaling pathwayOverexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancerStructural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4Use of adenoviral E1A protein to analyze K18 promoter deregulation in colon carcinoma cells discloses a role for CtBP1 and BRCA1.Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer.Structural and Functional Analysis of the DEAF-1 and BS69 MYND DomainsIkaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repressionThe LIM domain: from the cytoskeleton to the nucleusBRCA1 and Oxidative StressDownstream targets of Lmo4 are modulated by cisplatin in the inner ear of Wistar ratsInactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiencyDefective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.The highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of the pituitary glycoprotein hormone alpha-subunit (alpha GSU) gene.DNA double strand break repair and its association with inherited predispositions to breast cancerZinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients.Integrative genomics identifies LMO1 as a neuroblastoma oncogene.Cisplatin-induced ototoxicity is mediated by nitroxidative modification of cochlear proteins characterized by nitration of Lmo4Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes.The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein-protein interaction.Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic.The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward.Stem cells in normal breast development and breast cancer.LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer).A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 geneProteomics of TGF-beta signaling and its impact on breast cancer.Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma.Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development.Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures.LIM only 4 is overexpressed in late stage pancreas cancerTargeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicityRAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205.Prognostic value of CtIP/RBBP8 expression in breast cancer.Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation.
P2860
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P2860
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity
description
2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@ast
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en-gb
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
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type
label
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@ast
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en-gb
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@nl
prefLabel
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@ast
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en-gb
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
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P2093
P2860
P3181
P356
P1476
The LIM domain protein LMO4 in ...... A1 and inhibits BRCA1 activity
@en
P2093
Benjamin Peng
Eleanor Y M Sum
Jane E Visvader
Junjie Chen
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P304
P3181
P356
10.1074/JBC.M110603200
P407
P577
2001-12-18T00:00:00Z