Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1 - Test2 - elhamkhani - TriplyDB

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma Sustained translational repression by eIF2α-P mediates prion neurodegeneration Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress Protein Folding and Mechanisms of Proteostasis Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway Emerging functions of the unfolded protein response in immunity Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p.The unfolded protein response: from stress pathway to homeostatic regulation Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress Molecular mechanisms of human IRE1 activation through dimerization and ligand binding The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?Regulation of basal cellular physiology by the homeostatic unfolded protein response HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing.Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease.Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.Phosphoregulation of Ire1 RNase splicing activity.Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana Getting the better of ER stress.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.Endoplasmic reticulum stress sensing in the unfolded protein response Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila.Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress.Inositol-requiring enzyme 1 inhibits respiratory syncytial virus replication.

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Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

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2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Flavonol Activation Defines an ...... he Kinase-RNase Domain of IRE1

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Flavonol Activation Defines an ...... he Kinase-RNase Domain of IRE1

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Cole M Haynes

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R Luke Wiseman

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Yuhong Zhang

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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10.1016/J.MOLCEL.2010.04.001

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2

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Heather P Harding

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2010-04-23T00:00:00Z

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