Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
about
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferationLoss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in miceC11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilizationMetabolic regulation of mitochondrial dynamicsMitochondrial Quality Control and Muscle Mass MaintenanceMitochondrial dynamics in cardiovascular health and diseaseMitochondrial morphology-emerging role in bioenergeticsCell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative diseaseMitophagy: mechanisms, pathophysiological roles, and analysisMitochondrial form and functionRegulation of the intrinsic apoptosis pathway by reactive oxygen speciesMorphological control of mitochondrial bioenergeticsThe pathways of mitophagy for quality control and clearance of mitochondriaMitochondrial quality control: decommissioning power plants in neurodegenerative diseasesQuality control in mitochondria: use it, break it, fix it, trash itMetabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilizationA stress-responsive system for mitochondrial protein degradationWhat is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future researchMitochondrial protein quality control: the mechanisms guarding mitochondrial healthMitochondrial dynamics and viral infections: A close nexusHomozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentationThe i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fissionYME1L degradation reduces mitochondrial proteolytic capacity during oxidative stressA novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulationImbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in miceMitochondrial function in vascular endothelial cell in diabetesNDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagyMitochondrial morphology in metabolic diseasesMitochondrial dynamics and mitochondrial quality controlMitochondrial division and fusion in metabolismMitochondria: in sickness and in healthMitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARLMitochondrial fission, fusion, and stressLoss of Yme1L perturbates mitochondrial dynamics.Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation.Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeastOMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.
P2860
Q24302280-D888B4AC-1DB7-419E-BCAA-33DD3969D267Q24307976-276D954E-2B19-42E6-B219-F89850937886Q24315727-CB7F9D7E-4364-4004-AFC3-7B228E2DCDE8Q26768130-582C9349-B819-42F6-AF77-B854FF82CFC6Q26770420-D6067B30-2CA7-4F50-A852-E48EA4374F36Q26820835-120D5494-A439-4CFE-9638-644030C7A9BEQ26852770-4CB467DC-9408-480C-8A4B-3EE254105A98Q26853356-82B6419A-3495-4BF9-B3D4-825A7E382CDEQ26865743-C52461FB-600C-4E21-BFB7-2F17F1613E67Q26866448-ACB772B8-6BE6-4B1B-8061-D7BF479031FDQ26995793-C60B73B3-1D5C-4E93-B744-BD818A3DC275Q27006036-AF81E916-197E-46D3-9773-869FA9CCFAAEQ27009206-EA1065FA-DA76-4283-AC75-6DB59FBCAABCQ27009213-A8DECC94-4D81-41BE-86D5-9251BC7659F0Q27011609-B5DC2B7D-002F-41C1-896A-55C7A0B0ABC6Q27330478-27A575D9-DD8B-4A59-A1A3-906203572020Q27675658-13F59BC9-BED2-4DF2-BF52-B4058FE199F8Q27933297-5B4A9499-00AE-4FC8-A1C4-119E27D6420FQ28081668-75968897-80C3-4F6C-98C4-B06D6A57C0CDQ28083423-B787085F-182A-44FD-846E-9CF1959C10ACQ28083493-D83FD31A-6499-42EA-8029-382FE037C465Q28117328-302A2C89-8808-4B08-A0EF-39DB1B0E2525Q28235694-209BFD74-BBBB-444D-A9FE-487B632F6429Q28252350-4E6533D0-0A66-4DC4-8B66-93BB74D80DE4Q28269042-B8AC5D3C-DB2E-4791-84DA-4BB2E9C1497CQ28272272-8531A37C-F432-4E32-9F02-23ADC4605E41Q28383025-6D1E3350-9117-457B-87AE-E04EAF99E7DDQ28384264-C7AC1B4C-791F-496C-96AE-7346A568C8FBQ28385060-C7D0181B-5891-42A4-ADA0-3B437B269639Q28386855-DCFFFD18-8D89-48BC-97A8-83290D930376Q28390964-EB2F8913-1854-4E34-A328-8A603503CB58Q29614825-8ACCFDBC-220E-4E9D-A5B5-9A27654B8B5DQ29615624-5D526FA3-3FC2-4579-ABC5-149044B8FA23Q29616536-84425401-C416-403A-A866-DA6ABA074CEEQ30571481-9ABDFA05-A21B-48F1-9CAD-F5023A988732Q30578089-45C9AE9E-0D2E-4769-9D09-FB00836B1C4BQ33599185-30A428D5-E363-4BED-982C-7AFC66901048Q33638683-1D437FA6-55B5-4E4A-9ED0-F97C0CFEEC2CQ33676633-E08613E6-DB0A-4853-A3C6-02472E3CF4D2Q33701546-3C0FF398-71DF-4801-B36F-9757EE43BEF6
P2860
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@ast
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en-gb
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@nl
type
label
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@ast
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en-gb
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@nl
prefLabel
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@ast
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en-gb
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@nl
P2093
P2860
P921
P3181
P356
P1476
Inducible proteolytic inactiva ...... A1 protease in mammalian cells
@en
P2093
Alexander M van der Bliek
Brian Head
Lorena Griparic
Mandana Amiri
Shilpa Gandre-Babbe
P2860
P304
P3181
P356
10.1083/JCB.200906083
P407
P577
2009-12-28T00:00:00Z