Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA
about
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAsThe organization and regulation of mRNA-protein complexesSurprises in the 3'-end: 'U' can decide too!Threading the barrel of the RNA exosomeProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsPoly(A) polymerase (PAP) diversity in gene expression--star-PAP vs canonical PAPHuman Mendelian diseases related to abnormalities of the RNA exosome or its cofactorsCytoplasmic mRNA turnover and ageingMechanisms of microRNA turnoverMechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathwayDetection of 3'-end RNA uridylation with a protein nanopore.Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis.Uridylation by TUT4 and TUT7 marks mRNA for degradation.Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-productA retrovirus packages nascent host noncoding RNAs from a novel surveillance pathwayThe 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.Effects of post-mortem and physical degradation on RNA integrity and quality.Identification of factors involved in target RNA-directed microRNA degradation.Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAsArabidopsis AtRRP44A is the functional homolog of Rrp44/Dis3, an exosome component, is essential for viability and is required for RNA processing and degradationTUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAsMolecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAsMultiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.A novel role for the 3'-5' exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth.A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification.Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors.Deadenylation: enzymes, regulation, and functional implications.Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye.Exosome substrate targeting: the long and short of it.The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.A DIStinctively novel exoribonuclease that really likes U.The epigenetic landscape of renal cancer.Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.Comparison of preribosomal RNA processing pathways in yeast, plant and human cells - focus on coordinated action of endo- and exoribonucleases.Distinct 18S rRNA precursors are targets of the exosome complex, the exoribonuclease RRP6L2 and the terminal nucleotidyltransferase TRL in Arabidopsis thaliana.
P2860
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P248
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P2860
Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@ast
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en-gb
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@nl
type
label
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@ast
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en-gb
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@nl
prefLabel
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@ast
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en-gb
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@nl
P2860
P50
P3181
P356
P1433
P1476
Exonuclease hDIS3L2 specifies ...... hway of human cytoplasmic mRNA
@en
P2093
Christian K Damgaard
Michal Lubas
P2860
P304
P3181
P356
10.1038/EMBOJ.2013.135
P407
P577
2013-07-03T00:00:00Z