Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.
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The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseasePrimary plasma cell leukemia 2.0: advances in biology and clinical management.Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns.The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M(3)P).A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species.Self-assembly of c-myc DNA promoted by a single enantiomer ruthenium complex as a potential nuclear targeting gene carrierTargeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors.Utilizing next-generation sequencing in the management of multiple myeloma.Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast.The molecular spectrum and clinical impact of DIS3 mutations in multiple myeloma.Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.Comparison of preribosomal RNA processing pathways in yeast, plant and human cells - focus on coordinated action of endo- and exoribonucleases.Comprehensive genomic profiling of IgM multiple myeloma identifies IRF4 as a prognostic marker.Structural insights into RNA unwinding and degradation by RNase R.Versatile approach for functional analysis of human proteins and efficient stable cell line generation using FLP-mediated recombination system.RNA surveillance by the nuclear RNA exosome: mechanisms and significance.DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.Distinct and evolutionary conserved structural features of the human nuclear exosome complex
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Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Multiple myeloma-associated hD ...... in as a potential drug target.
@en
Multiple myeloma-associated hD ...... in as a potential drug target.
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type
label
Multiple myeloma-associated hD ...... in as a potential drug target.
@en
Multiple myeloma-associated hD ...... in as a potential drug target.
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prefLabel
Multiple myeloma-associated hD ...... in as a potential drug target.
@en
Multiple myeloma-associated hD ...... in as a potential drug target.
@nl
P2093
P2860
P50
P356
P1476
Multiple myeloma-associated hD ...... in as a potential drug target.
@en
P2093
Ewelina P Owczarek
Jakub Gruchota
Katarzyna Kalisiak
Krystian Stodus
P2860
P304
P356
10.1093/NAR/GKT930
P407
P577
2013-10-22T00:00:00Z