A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1
about
The Lowe syndrome protein OCRL1 is involved in primary cilia assemblyOCRL localizes to the primary cilium: a new role for cilia in Lowe syndromeHow PI3K-derived lipids control cell divisionThe cellular and physiological functions of the Lowe syndrome protein OCRL1Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesPhosphoinositides: tiny lipids with giant impact on cell regulationOCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.Recognition of the F&H; motif by the Lowe syndrome protein OCRLProtein LidA from Legionella is a Rab GTPase supereffectorThe activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI bindingIntermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRABPhosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins.Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP)Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.OCRL1 modulates cilia length in renal epithelial cells.An Unusual Case of Peters Plus Syndrome with Sexual Ambiguity and Absence of Mutations in the B3GALTL Gene.Spatiotemporal imaging of small GTPases activity in live cellsInositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.Direct targeting of Rab-GTPase-effector interactions.Multivalency in Rab effector interactions.Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity.Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase.Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein.Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8A novel and de novo deletion in the OCRL1 gene associated with a severe form of Lowe syndrome.Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking.Inferring joint sequence-structural determinants of protein functional specificity.
P2860
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P2860
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1
description
2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@ast
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en-gb
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@nl
type
label
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@ast
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en-gb
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@nl
prefLabel
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@ast
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en-gb
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
A structural basis for Lowe sy ...... he Rab-binding domain of OCRL1
@en
P2093
Kai S Erdmann
Nina Hagemann
Stefan Schoebel
Xiaomin Hou
P2860
P304
P3181
P356
10.1038/EMBOJ.2011.60
P407
P577
2011-04-20T00:00:00Z