Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
about
A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1The Lowe syndrome protein OCRL1 is involved in primary cilia assemblySpecific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathwaysOCRL localizes to the primary cilium: a new role for cilia in Lowe syndromeThe PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathwayA PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolismProteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles.A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathwayTwo closely related endocytic proteins that share a common OCRL-binding motif with APPL1Differential clathrin binding and subcellular localization of OCRL1 splice isoformsOCRL1 function in renal epithelial membrane trafficAll known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 bindingInsulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5The cellular and physiological functions of the Lowe syndrome protein OCRL1Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides in the mammalian endo-lysosomal networkOCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.Recognition of the F&H; motif by the Lowe syndrome protein OCRLSac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.Membrane recruitment of scaffold proteins drives specific signalingInteraction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptorsCrystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndromeRole of Rab GTPases in membrane traffic and cell physiologyImpaired neural development in a zebrafish model for Lowe syndromeYersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scissionClinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa.Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion.Are Rab proteins the link between Golgi organization and membrane trafficking?Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells.The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamicsCiliopathies: the trafficking connection.Toward a comprehensive map of the effectors of rab GTPases.Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.Rab6 dependent post-Golgi trafficking of HSV1 envelope proteins to sites of virus envelopment.Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210Anchors for effectors: subversion of phosphoinositide lipids by legionella.A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.Rab proteins and the compartmentalization of the endosomal system
P2860
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P2860
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
description
2006 nî lūn-bûn
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2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@ast
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en-gb
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@nl
type
label
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@ast
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en-gb
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@nl
prefLabel
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@ast
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en-gb
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@nl
P2093
P2860
P3181
P356
P1433
P1476
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
@en
P2093
Alison Skippen
Eddie McKenzie
Martin Lowe
Noora Hyvola
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601274
P407
P577
2006-08-23T00:00:00Z