Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence
about
UXT plays dual opposing roles on SARM-induced apoptosisSARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neuronsUbiquitination by SAG regulates macrophage survival/death and immune response during infection.The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3T-cell death following immune activation is mediated by mitochondria-localized SARM.Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.Sarm1-mediated axon degeneration requires both SAM and TIR interactionsSARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.Resveratrol inhibits the TRIF-dependent pathway by upregulating sterile alpha and armadillo motif protein, contributing to anti-inflammatory effects after respiratory syncytial virus infection.Wallerian degeneration: an emerging axon death pathway linking injury and disease.Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative DisordersResolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis.Innate immune regulation by toll-like receptors in the brain.A radiation hybrid map of chromosome 1D reveals synteny conservation at a wheat speciation locus.
P2860
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P2860
Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@ast
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@en
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@nl
type
label
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@ast
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@en
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@nl
prefLabel
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@ast
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@en
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@nl
P2093
P2860
P921
P356
P1433
P1476
Targeting of pro-apoptotic TLR ...... esidues in the signal sequence
@en
P2093
Jeak Ling Ding
Jianzhu Chen
Laishram Pradeepkumar Singh
Porkodi Panneerselvam
P2860
P304
P356
10.1042/BJ20111653
P407
P577
2012-03-01T00:00:00Z