Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells
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Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancersInteractions of the human MCM-BP protein with MCM complex components and Dbf4Replication licensing and cancer--a fatal entanglement?Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene for Autosomal Dominant Nonsyndromic Deafness in a Chinese FamilyRegulation of replication fork progression through histone supply and demandREDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligaseDbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damageMicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsPhosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.Large scale phosphoproteome analysis of LNCaP human prostate cancer cellsCUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.Cell cycle regulation of DNA replication.Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulationPhosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry.Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.The human intra-S checkpoint response to UVC-induced DNA damage.Phosphoproteomic analyses of L-02 liver cells exposed to trichloroethylene.Mechanisms and regulation of DNA replication initiation in eukaryotes.Depletion of minichromosome maintenance protein 7 inhibits glioblastoma multiforme tumor growth in vivo.3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors.Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.Identification of stimulators and inhibitors of Cdc7 kinase in vitro.RNAi-mediated knockdown of MCM7 gene on CML cells and its therapeutic potential for leukemia.A synthetic human kinase can control cell cycle progression in budding yeast.DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae.Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability.p53 gain-of-function mutations increase Cdc7-dependent replication initiation.Maturation-associated Dbf4 expression is essential for mouse zygotic DNA replication.Simulated microgravity, Mars gravity, and 2g hypergravity affect cell cycle regulation, ribosome biogenesis, and epigenetics in Arabidopsis cell cultures.Biochemical characterization of fragmented human MCM2.Cdc7 is an active kinase in human cancer cells undergoing replication stress.
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P2860
Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells
description
2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Essential role of phosphorylat ...... replication in mammalian cells
@ast
Essential role of phosphorylat ...... replication in mammalian cells
@en
Essential role of phosphorylat ...... replication in mammalian cells
@en-gb
Essential role of phosphorylat ...... replication in mammalian cells
@nl
type
label
Essential role of phosphorylat ...... replication in mammalian cells
@ast
Essential role of phosphorylat ...... replication in mammalian cells
@en
Essential role of phosphorylat ...... replication in mammalian cells
@en-gb
Essential role of phosphorylat ...... replication in mammalian cells
@nl
prefLabel
Essential role of phosphorylat ...... replication in mammalian cells
@ast
Essential role of phosphorylat ...... replication in mammalian cells
@en
Essential role of phosphorylat ...... replication in mammalian cells
@en-gb
Essential role of phosphorylat ...... replication in mammalian cells
@nl
P2093
P2860
P921
P356
P1476
Essential role of phosphorylat ...... replication in mammalian cells
@en
P2093
Scott B Ficarro
Toshiya Tsuji
P2860
P304
P356
10.1091/MBC.E06-03-0241
P407
P577
2006-10-01T00:00:00Z