Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
about
PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cellsEssential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cellsThe regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsCell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separaseCdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingChromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisRoscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteinsRegulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidizationIdentification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replicationHuman cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Identification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding propertiesStability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleAssembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinaseCell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunitCdc7-Dbf4 and the human S checkpoint response to UVCSelective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammalsTransforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor proteinThe Non-Canonical Role of Aurora-A in DNA ReplicationGenomic instability in cancer.Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteinsThe SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradationCyclin-dependent kinases prevent DNA re-replication through multiple mechanismsCyclin-dependent kinases phosphorylate human Cdt1 and induce its degradationCDC6: from DNA replication to cell cycle checkpoints and oncogenesisCellular checkpoint mechanisms monitoring proper initiation of DNA replicationAnaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpointCdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.The APC/C inhibitor, Emi1, is essential for prevention of rereplicationRetinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells.RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.Xenopus Cdc6 performs separate functions in initiating DNA replicationAssociation of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures.cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA.Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells.
P2860
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P2860
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@ast
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@en
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@nl
type
label
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@ast
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@en
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@nl
prefLabel
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@ast
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@en
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@nl
P2093
P2860
P356
P1476
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.11.6193
P407
P577
1999-05-25T00:00:00Z