A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
about
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminOCRL localizes to the primary cilium: a new role for cilia in Lowe syndromeThe PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathwayTwo closely related endocytic proteins that share a common OCRL-binding motif with APPL1The emerging role of phosphoinositide clustering in intracellular trafficking and signal transductionHow PI3K-derived lipids control cell divisionThe cellular and physiological functions of the Lowe syndrome protein OCRL1Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular traffickingInositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesPhosphoinositides: tiny lipids with giant impact on cell regulationRecognition of the F&H; motif by the Lowe syndrome protein OCRLSac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recyclingCrystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndromePhosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and sizeImpaired neural development in a zebrafish model for Lowe syndromePhosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection.SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.Ocular Pathology of Oculocerebrorenal Syndrome of Lowe: Novel Mutations and Genotype-Phenotype AnalysisThe inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamicsA novel Rho-like protein TbRHP is involved in spindle formation and mitosis in trypanosomes.Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe SyndromeMouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy.A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis.Endocytic accessory factors and regulation of clathrin-mediated endocytosisThe Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse PlateletsThe 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRLDigenic mutations of human OCRL paralogs in Dent's disease type 2 associated with Chiari I malformation.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.Synaptic vesicle endocytosis.Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.
P2860
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P2860
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@ast
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en-gb
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@nl
type
label
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@ast
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en-gb
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@nl
prefLabel
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@ast
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en-gb
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@nl
P2093
P2860
P3181
P356
P1433
P1476
A PH domain within OCRL bridge ...... to phosphoinositide metabolism
@en
P2093
Daniel M Balkin
Fenghua Hu
Kai S Erdmann
Livia Tomasini
Michael E Hodsdon
Moonsoo M Jin
P2860
P304
P3181
P356
10.1038/EMBOJ.2009.155
P407
P577
2009-07-08T00:00:00Z