DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
about
Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damageDYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligaseATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damageProtective effects and mechanisms of sirtuins in the nervous systemAnother fork in the road--life or death decisions by the tumour suppressor p53Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionAn African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelEngagement of DYRK2 in proper control for cell divisionPim-1 controls NF-kappaB signalling by stabilizing RelA/p65Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsNovel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress.Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma.Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.Interplay between Mdm2 and HIPK2 in the DNA damage response.Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.Role of p53 serine 46 in p53 target gene regulation.Posttranslational modification of p53: cooperative integrators of functionDeep evolutionary conservation of an intramolecular protein kinase activation mechanism.Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifsDyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activityEffects on human transcriptome of mutated BRCA1 BRCT domain: a microarray study.p53 post-translational modification: deregulated in tumorigenesisUnfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Molecular basis for modulation of the p53 target selectivity by KLF4.MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathwayInteraction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B.RETRACTED: Microarray analysis for differentially expressed genes of patients undergoing total knee arthroplasty with ischemia preconditioning.Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) as a novel marker in T1 high-grade and T2 bladder cancer patients receiving neoadjuvant chemotherapyDYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation.Pathway Implications of Aberrant Global Methylation in Adrenocortical Cancer3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways.
P2860
Q24297839-637D1D76-E3AF-42AA-8220-8CC471146632Q24300074-7BC4DC02-7C5D-42C3-AD78-AABFE5257B94Q24321736-1D9537CC-B44E-4988-87B8-92513FE0B5CDQ24336416-E3F7DAAB-AC6B-45CE-A01E-44A546DC8E0FQ26825585-876EAC6E-FB45-492F-96BE-BCE965BCF2C4Q27026310-A07DCC15-6142-43F2-8037-D333FAAF178BQ27678087-2F3EEAE0-96AF-4180-B90D-0B757224F01FQ27853369-4C4196B0-E3B8-468D-BF43-4E36320AD780Q28081810-968F4131-173F-4541-8B06-90421A01CAF0Q28264675-28B4036B-03A9-443D-BA8D-3644ED061075Q28541616-28144ECF-2AB7-4F7A-AB18-C7533E9C9FD5Q28591067-5C12D1FA-6C5F-4686-9C0B-D5CFED59F021Q30845691-92E14127-27F4-4C3D-845A-1DC860B9C3BBQ31164546-B7A84B35-3815-462B-9816-1509466AE74EQ33591648-8C461868-2E86-44D2-936A-CC047161E225Q33646091-AA9BB83E-D1CF-42D8-B4FC-62BFC2462936Q33656086-70427B65-00E6-4ED5-B8B9-FCF5AA9C520BQ33725442-18EFE431-F871-43F6-B7F8-5A2BE661AEB3Q33823007-5BB717ED-7AAB-437E-A772-1CABFB29053EQ33843352-E7CDFE71-A0C7-4494-BEC1-B6F2B0B8EAB2Q33899450-60C78EA6-4027-4842-9972-699E13612F91Q34123845-EB4AE296-D91D-4212-BDD9-81915E9637D5Q34158315-1CC06807-4A56-443E-BE6C-17AA86114A0BQ34181652-08A6CFE8-BFE1-4717-BC2D-8CD0D517A467Q34274477-F5B1E751-AE67-49A8-97AB-6D4861565417Q34286239-13423053-C530-4DA3-97BB-92BE89A0CBEEQ34300569-861A1B93-5495-4DDD-A2EE-47667C62EE65Q34322386-3F8BF3C8-BE3D-4783-8077-DA89DA0ECCBEQ34464874-27247C2A-9C45-455E-9752-BC0F0FF87FD9Q34504863-5F04EBE4-3F9B-4A34-ADB2-26D8BD9F7732Q34551194-5BED9D54-49CC-4145-845E-FC609796585AQ34650882-A367C115-722B-4A93-929A-06CDB4E80AAEQ34981538-7274F533-C598-4196-A62F-928B0693BC4CQ35106800-0A6EE36F-E4D3-4048-9910-BF863CB7AE6DQ35667815-6ABD11ED-55FE-4DC7-8BE4-1ACD16DE89D3Q35788640-1933685E-5614-4244-BA33-EFC906A2C089Q35952358-2BA270C0-DF48-44FD-9CC2-06302B68EEDFQ35994548-F453EF6E-2699-4E58-AD49-7E2051E03984Q36105658-3C62CCE8-05AD-4027-9EC1-4807E10AE146Q36557240-199433CA-ED52-43A3-B5EA-21A7609AB02B
P2860
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@ast
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en-gb
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@nl
type
label
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@ast
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en-gb
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@nl
prefLabel
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@ast
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en-gb
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@nl
P2093
P921
P3181
P1433
P1476
DYRK2 is targeted to the nucle ...... optotic response to DNA damage
@en
P2093
Keishi Nihira
Kiyotsugu Yoshida
Naoe Taira
Tomoko Yamaguchi
Yoshio Miki
P304
P3181
P356
10.1016/J.MOLCEL.2007.02.007
P407
P577
2007-03-09T00:00:00Z