ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionEngagement of DYRK2 in proper control for cell divisionFUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damageExploring the link between germline and somatic genetic alterations in breast carcinogenesis.Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.Dynamics of DNA damage induced pathways to cancerDYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation.Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways.Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradationDNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destructionInduction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.The cell death machinery governed by the p53 tumor suppressor in response to DNA damage.Beyond ATM: the protein kinase landscape of the DNA damage response.MDM2's social network.Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer.The Many Faces of MDM2 Binding Partners.Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisonsCHK2 stability is regulated by the E3 ubiquitin ligase SIAH2.Regulation of TP53 Activity through PhosphorylationATM phosphorylates DYRK2MDM2 ubiquitinates DYRK2Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control.Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis
P2860
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P2860
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage
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2010 nî lūn-bûn
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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2010 թվականի փետրվարին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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ATM augments nuclear stabiliza ...... optotic response to DNA damage
@ast
ATM augments nuclear stabiliza ...... optotic response to DNA damage
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ATM augments nuclear stabiliza ...... optotic response to DNA damage
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ATM augments nuclear stabiliza ...... optotic response to DNA damage
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ATM augments nuclear stabiliza ...... optotic response to DNA damage
@ast
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@en
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@en-gb
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@nl
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ATM augments nuclear stabiliza ...... optotic response to DNA damage
@ast
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@en
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@en-gb
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@nl
P2093
P2860
P921
P3181
P356
P1476
ATM augments nuclear stabiliza ...... optotic response to DNA damage
@en
P2093
Hiroyuki Yamamoto
Kiyotsugu Yoshida
Naoe Taira
Tomoko Yamaguchi
Yoshio Miki
P2860
P304
P3181
P356
10.1074/JBC.M109.042341
P407
P577
2010-02-12T00:00:00Z