Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeCase report of novel DYRK1A mutations in 2 individuals with syndromic intellectual disability and a review of the literatureThe DYRK-family kinase Pom1 phosphorylates the F-BAR protein Cdc15 to prevent division at cell poles.Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteineIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesSelective inhibition of the kinase DYRK1A by targeting its folding processStructural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders.Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme.Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.Hyper-accumulation of starch and oil in a Chlamydomonas mutant affected in a plant-specific DYRK kinase.Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and IDSite-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.Identification of suppressors of mbk-2/DYRK by whole-genome sequencingDYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.Unmasking determinants of specificity in the human kinome.Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity.10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.Mechanism of dual specificity kinase activity of DYRK1A.Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism.Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control.Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling.Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A.Identification of Plant Homologues of Dual Specificity Yak1-Related Kinases
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Q26745413-13C02014-A9A8-4406-A8C5-F0A59BD1C3B1Q26765984-98D1EE2A-FBBA-4A5B-A8E8-6B210F2BE7E8Q27309376-D5033810-33BF-4D7F-B669-18B9633B1C76Q27682291-ED2FB882-162E-478D-83D4-391DDD70858EQ27700733-315204B3-C4E3-4D09-BFFC-1DF69525BFE7Q28270556-082D5279-B565-402C-8344-7508E664B774Q28834235-199EFF57-DFE4-4691-B412-6B726FAFF109Q33614798-6B93B777-7BD4-430D-B160-D6D527DB42C0Q35157014-963E55AF-3CF8-4401-AE97-FC4A6F977FEDQ35380915-559D7E90-7390-47C6-AD7E-14FDF4CFB535Q35583330-EB4B9CE6-A3B5-4E96-9F33-A2D3F1EC305CQ35733743-628E9660-5003-4DB5-9EE1-09755AF8DA15Q35950573-7E026949-2CB2-4B46-9FA7-7F4D2EF753B3Q35991718-823C0136-9686-4160-9FF4-D8F0C4612F1FQ36833345-66E214A8-0A12-4AE2-815E-8EE2A62D3428Q37597371-040BBD8D-1277-42A7-9899-5EA4E79E5308Q41124666-A637E4C8-8C28-4C73-A315-58AA14BF061FQ41782221-05FB9BC8-3D04-4D72-BA69-6A727032F656Q41950534-6748FA99-068A-425D-9C9C-4586F5841C42Q42100110-3D2A6CEF-67EC-4BA3-8203-9CA5DB8EE5E6Q42353177-9EB94C0C-4119-4270-B03C-5B8F246FE832Q50871004-AA16DFD6-F0CC-4B2F-913F-AB5CE31ECC04Q52560273-6955977B-BB90-4914-BAB8-A1709427ED9BQ54117942-7D42B4A0-5A5C-45AF-9C2E-F01C3C9ABBF9Q54201365-52D1F425-7EB3-410E-A9A7-C7D415496EEBQ54979041-5F7F99A7-EE18-43DF-9D69-FF69DD44A6B6Q59052323-FA5EFABC-53A8-475B-A098-B24480232896
P2860
Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition
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2013 nî lūn-bûn
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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structures of Down Syndrome Ki ...... tion and Substrate Recognition
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Structures of Down Syndrome Ki ...... tion and Substrate Recognition
@en
Structures of Down Syndrome Ki ...... tion and Substrate Recognition
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type
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Structures of Down Syndrome Ki ...... tion and Substrate Recognition
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Structures of Down Syndrome Ki ...... tion and Substrate Recognition
@en
Structures of Down Syndrome Ki ...... tion and Substrate Recognition
@nl
prefLabel
Structures of Down Syndrome Ki ...... tion and Substrate Recognition
@ast
Structures of Down Syndrome Ki ...... tion and Substrate Recognition
@en
Structures of Down Syndrome Ki ...... tion and Substrate Recognition
@nl
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Structures of Down Syndrome Ki ...... tion and Substrate Recognition
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P2093
Annette K Roos
Jeyanthy Eswaran
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P304
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10.1016/J.STR.2013.03.012
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2013-06-04T00:00:00Z