The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
about
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distributionNRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE ConsortiumFTO: the first gene contributing to common forms of human obesityALKBH4-dependent demethylation of actin regulates actomyosin dynamics.N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTOMammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decodingHuman AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survivalALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertilityHuman AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNAOxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOSpectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNAHuman AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sitesALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNAHuman ALKBH7 is required for alkylation and oxidation-induced programmed necrosisThe bigger picture of FTO: the first GWAS-identified obesity geneIron-catalysed oxidation intermediates captured in a DNA repair dioxygenaseComprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codonsGenetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traitsFive years of GWAS discoveryBeyond the fourth wave of genome-wide obesity association studiesA commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyA non-heme iron-mediated chemical demethylation in DNA and RNAThe AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNAHypothalamic FTO is associated with the regulation of energy intake not feeding rewardAdenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensingSix new loci associated with body mass index highlight a neuronal influence on body weight regulationVitamin C: update on physiology and pharmacologyRecent advances in dynamic m6A RNA modificationRole of FTO in Adipocyte Development and Function: Recent InsightsInsights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related TraitsRNA epigeneticsStructure and function of dioxygenases in histone demethylation and DNA/RNA demethylationFat: an evolving issueN6-methyl-adenosine modification in messenger and long non-coding RNAAda response - a strategy for repair of alkylated DNA in bacteriaLoss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathiesAdult onset global loss of the fto gene alters body composition and metabolism in the mouseNeurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humansCrystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase
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P2860
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@ast
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en-gb
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@nl
type
label
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@ast
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en-gb
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@nl
prefLabel
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@ast
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en-gb
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@nl
P2093
P2860
P50
P921
P3181
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P1476
The obesity-associated FTO gen ...... ndent nucleic acid demethylase
@en
P2093
Barbara Sedgwick
Celia J Webby
Frances M Ashcroft
Juris Galvanovskis
Kirsty S Hewitson
Luke A McNeill
Marcella Ma
Peter Robins
Sharon Cunliffe
Thomas Gerken
P2860
P304
P3181
P356
10.1126/SCIENCE.1151710
P407
P50
P577
2007-11-08T00:00:00Z