Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase - Test2 - elhamkhani - TriplyDB

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

http://www.wikidata.org/entity/Q24595502

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ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility Vitamins C and E: beneficial effects from a mechanistic perspective Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase Duplex interrogation by a direct DNA repair protein in search of base damage Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues Involvement of Iron-Containing Proteins in Genome Integrity in Arabidopsis Thaliana Imposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine.Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics.Calorimetric assessment of Fe(2+) binding to α-ketoglutarate/taurine dioxygenase: ironing out the energetics of metal coordination by the 2-His-1-carboxylate facial triad.Photoaffinity labeling of transcription factors by DNA-templated crosslinking.Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions Lyn regulates inflammatory responses in Klebsiella pneumoniae infection via the p38/NF-κB pathway.Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB Protein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkB Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1)A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Cellular dynamics of RNA modification.Atg7 enhances host defense against infection via downregulation of superoxide but upregulation of nitric oxide Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2.Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding Nucleic acid modifications with epigenetic significance.AlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action.Substrate placement influences reactivity in non-heme Fe(II) halogenases and hydroxylases.Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB QM/MM free energy simulations: recent progress and challenges Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymes Nucleic acid oxidation in DNA damage repair and epigenetics DNA repair by reversal of DNA damage.Oxidative demethylation of DNA and RNA mediated by non-heme iron-dependent dioxygenases.

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P2860

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

http://www.wikidata.org/entity/Q24595502

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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Cai-Guang Yang

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Chuan He

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Guanhua Hou

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Guanqun Zheng

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Guifang Jia

http://www.w3.org/2001/XMLSchema#string

Qiang Cui

http://www.w3.org/2001/XMLSchema#string

Qing Dai

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Wen Zhang

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P2860

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Crystal structure of the FTO protein reveals basis for its substrate specificity

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

A non-heme iron-mediated chemical demethylation in DNA and RNA

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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