Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA - Test2 - elhamkhani - TriplyDB

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

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DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4 Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase A non-heme iron-mediated chemical demethylation in DNA and RNA The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA Identification of a novel, widespread, and functionally important PCNA-binding motif Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions Duplex interrogation by a direct DNA repair protein in search of base damage Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues Expanding chemical biology of 2-oxoglutarate oxygenases Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics.A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones ALKBH4 depletion in mice leads to spermatogenic defects.Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3 Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5 X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2.Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.Expression and sub-cellular localization of human ABH family molecules.Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage.DNA repair is indispensable for survival after acute inflammation.The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.

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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

http://www.wikidata.org/entity/Q24544017

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2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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Repair deficient mice reveal m ...... g 1meA and 3meC lesions in DNA

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SJ.EMBOJ.7601109

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The EMBO Journal

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Alexandra Bjørk

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Jeanette Ringvoll

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Karen Reite

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Knut H Lauritzen

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Line M Nordstrand

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Nina Beate Liabakk

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Per Arne Aas

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Pål Ø Falnes

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Richard William Doughty

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Vivi Talstad

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Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

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Hans Einar Krokan

Cathrine B Vågbø

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2006-05-17T00:00:00Z

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