An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
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Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53Y-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion SpecificityStructure of p73 DNA-binding domain tetramer modulates p73 transactivationStructure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertionStructural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeSolution structure and binding specificity of the p63 DNA binding domainDNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions.Crystal structure of the DNA-binding domain of Myelin-gene Regulatory FactorMolecular basis for modulation of the p53 target selectivity by KLF4.P53 conformational switching for selectivity may reveal a general solution for specific DNA binding.Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.Protein domain-level landscape of cancer-type-specific somatic mutations.Surf the post-translational modification network of p53 regulationLow-level p53 expression changes transactivation rules and reveals superactivating sequences.Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elementsOn the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes.Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xLStructural Evolution and Dynamics of the p53 Proteins.Full-length p53 tetramer bound to DNA and its quaternary dynamics.An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions.Recognition of Local DNA Structures by p53 Protein.Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain.Differential salt-induced dissociation of the p53 protein complexes with circular and linear plasmid DNA substrates suggest involvement of a sliding mechanism.Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling.The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.Molecular dynamics of the full-length p53 monomer.Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study.Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides.Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins.One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain.Conformational changes in DNA-binding proteins: Relationships with precomplex features and contributions to specificity and stabilityThe p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domainRevealing a human p53 universe
P2860
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P2860
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
An induced fit mechanism regul ...... to confer sequence specificity
@ast
An induced fit mechanism regul ...... to confer sequence specificity
@en
An induced fit mechanism regul ...... to confer sequence specificity
@en-gb
An induced fit mechanism regul ...... to confer sequence specificity
@nl
type
label
An induced fit mechanism regul ...... to confer sequence specificity
@ast
An induced fit mechanism regul ...... to confer sequence specificity
@en
An induced fit mechanism regul ...... to confer sequence specificity
@en-gb
An induced fit mechanism regul ...... to confer sequence specificity
@nl
prefLabel
An induced fit mechanism regul ...... to confer sequence specificity
@ast
An induced fit mechanism regul ...... to confer sequence specificity
@en
An induced fit mechanism regul ...... to confer sequence specificity
@en-gb
An induced fit mechanism regul ...... to confer sequence specificity
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
An induced fit mechanism regul ...... to confer sequence specificity
@en
P2093
Elena S Stavridi
Irina Petkova
Soheila Emamzadah
Thanos D Halazonetis
Tom J Petty
P2860
P304
P3181
P356
10.1038/EMBOJ.2011.127
P407
P577
2011-04-26T00:00:00Z