Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
about
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerStructures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elementsPliable DNA Conformation of Response Elements Bound to Transcription Factor p63Structure of p73 DNA-binding domain tetramer modulates p73 transactivationStructure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertionStructural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codep53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemPrevalence of syn nucleobases in the active sites of functional RNAsAn Integrated Mass Spectrometry Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor.Improved predictions of transcription factor binding sites using physicochemical features of DNA.Models incorporating chromatin modification data identify functionally important p53 binding sitesStructure, Stiffness and Substates of the Dickerson-Drew Dodecamer.Two p53 tetramers bind one consensus DNA response elementInsights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acidsInvestigating dynamic and energetic determinants of protein nucleic acid recognition: analysis of the zinc finger zif268-DNA complexes.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesTracing the protectors path from the germ line to the genome.Absence of a simple code: how transcription factors read the genomeThe transcriptional specificity of NF-κB dimers is coded within the κB DNA response elementsA historical account of Hoogsteen base-pairs in duplex DNA.Deconvolving the recognition of DNA shape from sequence.Variation in the mechanical unfolding pathway of p53DBD induced by interaction with p53 N-terminal region or DNA.Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNAGuanine to inosine substitution leads to large increases in the population of a transient G·C Hoogsteen base pairStructure and stability insights into tumour suppressor p53 evolutionary related proteins.DNA shape, genetic codes, and evolutionNew insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.Evolution of p53 transactivation specificity through the lens of a yeast-based functional assayMolecular dynamic simulation insights into the normal state and restoration of p53 function.Low-level p53 expression changes transactivation rules and reveals superactivating sequences.Computational mapping reveals dramatic effect of Hoogsteen breathing on duplex DNA reactivity with formaldehydeDomain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.Radioprobing the conformation of DNA in a p53-DNA complex.Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elementsProbing DNA shape and methylation state on a genomic scale with DNase I.NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers.
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P2860
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@ast
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@en
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@nl
type
label
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@ast
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@en
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@nl
prefLabel
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@ast
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@en
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@nl
P2093
P2860
P921
P3181
P356
P1476
Diversity in DNA recognition b ...... ures with Hoogsteen base pairs
@en
P2093
Dov Rabinovich
Malka Kitayner
Zippora Shakked
P2860
P2888
P3181
P356
10.1038/NSMB.1800
P407
P577
2010-04-01T00:00:00Z
P5875
P6179
1033761757