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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityComputational identification of a transiently open L1/S3 pocket for reactivation of mutant p53Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled TetramerDiversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairsStructures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elementsPliable DNA Conformation of Response Elements Bound to Transcription Factor p63Structure of p73 DNA-binding domain tetramer modulates p73 transactivationStructure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertionStructural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeCooperativity dominates the genomic organization of p53-response elements: a mechanistic viewLysine120 interactions with p53 response elements can allosterically direct p53 organization.Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acidsThe p53 Transcriptional Network Influences Microglia Behavior and NeuroinflammationTracing the protectors path from the germ line to the genome.A historical account of Hoogsteen base-pairs in duplex DNA.Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNALow-level p53 expression changes transactivation rules and reveals superactivating sequences.Radioprobing the conformation of DNA in a p53-DNA complex.Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elementsRotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest.Bioinformatic analysis of the protein/DNA interface.The tumor suppressor p53: from structures to drug discovery.Protein-Protein Interface and Disease: Perspective from Biomolecular Networks.Structural Evolution and Dynamics of the p53 Proteins.Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominanceStructure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study.Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets.Site-Specific Disulfide Crosslinked Nucleosomes with Enhanced Stability.Vinylsulfonamide and acrylamide modification of DNA for cross-linking with proteins.Diverse p53/DNA binding modes expand the repertoire of p53 response elements.Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal structure of a p53 core tetramer bound to DNA
@ast
Crystal structure of a p53 core tetramer bound to DNA
@en
Crystal structure of a p53 core tetramer bound to DNA
@nl
type
label
Crystal structure of a p53 core tetramer bound to DNA
@ast
Crystal structure of a p53 core tetramer bound to DNA
@en
Crystal structure of a p53 core tetramer bound to DNA
@nl
prefLabel
Crystal structure of a p53 core tetramer bound to DNA
@ast
Crystal structure of a p53 core tetramer bound to DNA
@en
Crystal structure of a p53 core tetramer bound to DNA
@nl
P2093
P2860
P356
P1433
P1476
Crystal structure of a p53 core tetramer bound to DNA
@en
P2093
K A Malecka
R Marmorstein
P2860
P2888
P304
P356
10.1038/ONC.2008.400
P407
P577
2009-01-22T00:00:00Z
P5875
P6179
1052650140