CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
about
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cellsSeveral distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusNoncoding RNA control of cellular senescenceDual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.miR-22 represses cancer progression by inducing cellular senescenceLong noncoding RNAs(lncRNAs) and the molecular hallmarks of aging.Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.Characterization of cellular senescence mechanisms in human corneal endothelial cells.The requirement for cyclin D function in tumor maintenance.Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature.p16INK4a-induced senescence is disabled by melanoma-associated mutationsDifferential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d.Let-7a functions as a tumor suppressor in Ewing's sarcoma cell lines partly by targeting cyclin-dependent kinase 6.p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Signaling through cyclin D-dependent kinases.Cyclin-dependent kinases as therapeutic targets in melanoma.Effect of reversine on cell cycle, apoptosis, and activation of hepatic stellate cells.Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulationContrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence.D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.The Immortal Senescence.MiR-124 inhibits cell proliferation in breast cancer through downregulation of CDK4.Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
P2860
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P248
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P2860
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@ast
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@en
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@nl
type
label
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@ast
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@en
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@nl
prefLabel
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@ast
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@en
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@nl
P2093
P2860
P921
P356
P1476
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
@en
P2093
Fiona Gregory
Gordon Peters
Janice Rowe
Margarida Ruas
Maria Starborg
Rebecca Jones
Robert Poolman
Sharon Brookes
P2860
P304
P356
10.1128/MCB.02286-06
P407
P577
2007-06-01T00:00:00Z