The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
about
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldariusRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringComposition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complexMRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patensRecruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domainDNA end resection: many nucleases make light workMre11 assembles linear DNA fragments into DNA damage signaling complexesDNA End Resection: Facts and MechanismsMetals in biology: defining metalloproteomesMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeKeeping it quiet: chromatin control of gammaherpesvirus latencyThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesEmerging critical roles of Fe-S clusters in DNA replication and repair.Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairThe Crystal Structure of the Hinge Domain of the Escherichia coli Structural Maintenance of Chromosomes Protein MukBABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexConserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair EnzymesStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingEnd-resection at DNA double-strand breaks in the three domains of lifeYeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.Biochemical analysis of the yeast condensin Smc2/4 complex: an ATPase that promotes knotting of circular DNA.KDM1 class flavin-dependent protein lysine demethylasesEnvisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairHinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA.RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Non-homologous end-joining, a sticky affairRad50 is dispensable for the maintenance and viability of postmitotic tissuesTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksThe Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosisDeveloping advanced X-ray scattering methods combined with crystallography and computationRole of mammalian Mre11 in classical and alternative nonhomologous end joiningC. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progressionRole of RAD52 epistasis group genes in homologous recombination and double-strand break repairDual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.
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P2860
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@ast
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en-gb
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@nl
type
label
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@ast
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en-gb
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@nl
prefLabel
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@ast
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en-gb
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@nl
P2093
P2860
P50
P3181
P356
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P1476
The Rad50 zinc-hook is a struc ...... n DNA recombination and repair
@en
P2093
Annette Karcher
Barbara A L Owen
Brendan Henderson
Cynthia T McMurray
James P Carney
Jean-Luc Bodmer
Robert A Zinkel
Takehiko Usui
P2860
P2888
P304
P3181
P356
10.1038/NATURE00922
P407
P577
2002-08-01T00:00:00Z
P5875
P6179
1008631593