Mre11 assembles linear DNA fragments into DNA damage signaling complexes - Test2 - elhamkhani - TriplyDB

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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ATM-dependent phosphorylation of ATF2 is required for the DNA damage response Disruption of mechanisms that prevent rereplication triggers a DNA damage response DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage The MRN-CtIP pathway is required for metaphase chromosome alignment.A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint.Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.ATR and ATM regulate the timing of DNA replication origin firing.Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks MCL-1 localizes to sites of DNA damage and regulates DNA damage response Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex Ploidy dictates repair pathway choice under DNA replication stress.Involvement of novel autophosphorylation sites in ATM activation The Rad50 coiled-coil domain is indispensable for Mre11 complex functions Checking on DNA damage in S phase.Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.The emerging role of nuclear architecture in DNA repair and genome maintenance.MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.Choreography of recombination proteins during the DNA damage response.

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

http://www.wikidata.org/entity/Q24796676

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

@zh-hk

2004年論文

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2004年論文

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2004年论文

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name

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@en

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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type

label

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@ast

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@en

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@nl

prefLabel

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@ast

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@en

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@nl

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JOURNAL.PBIO.0020110

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

@en

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Jean Gautier

http://www.w3.org/2001/XMLSchema#string

Max Gottesman

http://www.w3.org/2001/XMLSchema#string

Tanya Paull

http://www.w3.org/2001/XMLSchema#string

P2860

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

ATM-dependent phosphorylation of nibrin in response to radiation exposure

MDC1 is a mediator of the mammalian DNA damage checkpoint

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

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E110

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scholarly article

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4884318

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10.1371/JOURNAL.PBIO.0020110

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5

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2

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Vincenzo Costanzo

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2004-05-01T00:00:00Z

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8566462

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15138496

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406388

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