Gemin8 is required for the architecture and function of the survival motor neuron complex
about
Absence of gemin5 from SMN complexes in nuclear Cajal bodiesSMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediateMolecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpainRibonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPsSpinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?A cell system for phenotypic screening of modifiers of SMN2 gene expression and function.The Gemin associates of survival motor neuron are required for motor function in Drosophila.Disease mechanisms and therapeutic approaches in spinal muscular atrophy.Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms.Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organizationComparative Proteomic Analysis of Mature and Immature Oocytes of the Swamp Buffalo (Bubalus bubalis).Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly.Chaperoning ribonucleoprotein biogenesis in health and disease.SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpainGemin3 is an essential gene required for larval motor function and pupation in Drosophila.Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesisGem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases.Role of survival motor neuron complex components in small nuclear ribonucleoprotein assembly.Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis.Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation.SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities.Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm.
P2860
Q21284155-FB5A9A06-DB39-441E-A43D-7B4A9279C022Q28237155-F547FDD3-6E99-4E18-9FD7-EC8BD10551C8Q30994078-25303E81-84DE-4E62-A36B-216F421A37C6Q33300324-BA66D2FA-C3C5-41A4-BB45-7B6F1ABF7E7BQ33785933-A3C5F917-859E-4C6E-9CF4-66038D3D997BQ34964785-B9E3E695-4808-46F0-BAA6-EA0FB3461B25Q35082654-777D0120-812A-4251-8421-1F93E117CDDEQ35707832-8C18A1A0-DFAA-4737-BE12-4040A325E274Q35715801-63FFAB7C-D15A-4F8F-BDA1-70C91DED6FD3Q35991646-E304816E-A99C-43CD-AAE8-33181F1FFD08Q36512600-D546C0FA-FB27-400E-88AD-59F6F294C87EQ36559321-EFA972F9-2179-4718-90AF-99DBBD03F4DCQ36718950-31B023E6-2873-42A2-A43C-0467FE42C480Q36777301-53A26710-C6CD-4A4F-BDA7-E75BF50CCEFDQ36934614-F35999C5-EE64-4937-952D-C897E6E323E6Q37035061-22BE7F29-FBAE-4B5D-86EA-4705022BAEECQ37167931-B82C5C6F-4EB9-41EF-8FFF-FFE00781AAF3Q38197233-9D3BF96A-F3DC-4EB4-AF91-11451C0F7D77Q38207417-F4E6FC1F-826B-4BBB-B140-AB6673E7A19AQ39754200-3409456F-4D30-4471-BD2B-81B3257EF44BQ41899281-DB4C0D09-7FE1-41F2-AF85-9C3EDB5D0989Q41982437-C6B21BDE-4EF2-4EC6-ACE7-08230E16EFDCQ47742110-42C29DDE-1CB8-4455-8407-FBC8B974B904Q47885235-F3FED509-ECE5-4023-982C-6C5C7F9CBC0FQ48163982-DF6E761B-579F-47C3-9DA2-EB49A175ACC7
P2860
Gemin8 is required for the architecture and function of the survival motor neuron complex
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Gemin8 is required for the architecture and function of the survival motor neuron complex
@ast
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en-gb
Gemin8 is required for the architecture and function of the survival motor neuron complex
@nl
type
label
Gemin8 is required for the architecture and function of the survival motor neuron complex
@ast
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en-gb
Gemin8 is required for the architecture and function of the survival motor neuron complex
@nl
prefLabel
Gemin8 is required for the architecture and function of the survival motor neuron complex
@ast
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en-gb
Gemin8 is required for the architecture and function of the survival motor neuron complex
@nl
P2860
P356
P1476
Gemin8 is required for the architecture and function of the survival motor neuron complex
@en
P2093
Francesca Gabanella
Luciano Saieva
P2860
P304
37009-37016
P356
10.1074/JBC.M607505200
P407
P577
2006-10-05T00:00:00Z