Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex
about
Absence of gemin5 from SMN complexes in nuclear Cajal bodiesGemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assemblyGemin8 is required for the architecture and function of the survival motor neuron complexStructure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assemblyNumerous microRNPs in neuronal cells containing novel microRNAsHigh expression level of Tra2-β1 is responsible for increased SMN2 exon 7 inclusion in the testis of SMA miceA motor function for the DEAD-box RNA helicase, Gemin3, in DrosophilaFunctional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs.Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesisIn vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation proteinGemin5-snRNA interaction reveals an RNA binding function for WD repeat domainsSMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediateUnrip is a component of SMN complexes active in snRNP assemblyThe SMN complex: an assembly machine for RNPsRegulation of SMN protein stabilityA role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophyLymphotropic Herpesvirus saimiri uses the SMN complex to assemble Sm cores on its small RNAs.The role of nuclear bodies in gene expression and disease.Diverse expression of selected SMN complex proteins in humans with sporadic amyotrophic lateral sclerosis and in a transgenic rat model of familial form of the disease.Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPsThe Gemin associates of survival motor neuron are required for motor function in Drosophila.Molecular and cellular basis of spinal muscular atrophy.Expression of Muscle-Specific MiRNA 206 in the Progression of Disease in a Murine SMA ModelInhibition of U snRNP assembly by a virus-encoded proteinaseReconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organizationIdentification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4.SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing.Identification and characterization of the porcine (Sus scrofa) survival motor neuron (SMN1) gene: an animal model for therapeutic studiesMolecular functions of the SMN complex.SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpainsnRNAs contain specific SMN-binding domains that are essential for snRNP assemblySpinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexesGemin3 is an essential gene required for larval motor function and pupation in Drosophila.Splice-site pairing is an intrinsically high fidelity process.Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesisCis-active RNA elements (CREs) and picornavirus RNA replicationSpliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Spinal muscular atrophy and the antiapoptotic role of survival of motor neuron (SMN) protein.Gem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.Advances in understanding the role of disease-associated proteins in spinal muscular atrophy.
P2860
22fc498bbbad6f0ca72ab43312ba9dbcd53239e525e4eb6eb0237d220c8d46a16dfa40c3c88d91fc350c0b64886d380d23da6a5e0f9d3e4e4a9d8eae76d7b06c365e8596f98e5e442042f507ea050ba183b0211a3931a7d82d58f336924f2830c14c9540877d4420e2b82cb29fbc16a95f62eaacc7997467b82c7ae72ef6bbf29d61ba3bc1aee8d7f45e616cc028fb59adac6ff06697dc700d4c3a971019d040cd9936fb264b8c508c99a4e548a99d57e033b6f6
P248
Q21284155-115EFDEF-3CDD-4290-9B72-958FEF44307BQ24301969-348F3511-B67A-41BB-AF26-CFD525CD3E1EQ24306053-C394391C-768B-4A74-9A02-896143CDA8FCQ24319038-68C8BC43-D622-4532-AA89-1260C204DFD7Q24540181-C2E20F01-815A-4159-B879-AF4BDA5B0CA0Q27311317-6DB297AD-4821-4C30-8424-709D85F3BE06Q27313604-83AAB41B-CC6B-48C1-918F-738B713A2E96Q27865260-5DEACB01-6C6C-4D97-98DA-174C944C5E5BQ28115894-1AB62335-40BC-48B4-823D-513221DD93BDQ28116617-2F113F12-2798-4B94-8DA9-35BDBC01D7A6Q28117609-2A9C542F-DB79-4786-BB66-FEF3FEBFD8C7Q28237155-86E36392-2779-4B6E-81E0-845363B70918Q28246568-BF1278FA-56A7-478F-8E38-156CA4485D69Q28294580-1EA8885A-4B77-40F3-972F-9B132E7E93B0Q28304878-5FEBC689-325B-419E-99C3-C3F879492BE2Q28586960-76723844-F1E0-4F44-B5E5-EDC4A241260CQ33695616-8E5A2058-D18E-4658-910E-ED05E59CB7C8Q34038183-7FF4D179-CD58-4BC0-A79F-C6AEA456C7C0Q34046836-7D2A7951-C96C-4B6D-9CE1-2BAA12F0B066Q34230914-BB1CF16F-5791-41D0-95A7-6F336BB6648DQ35082654-A453B815-935F-4D0D-A69B-74244C0FB8A1Q35226376-CE1BC91D-5841-4633-844D-A571987B300BQ35647837-D8638812-E18F-4880-A0B8-31FCCF35DFC9Q35758087-A6EBDC1D-9764-434B-B6F8-85551EEE0E21Q35991646-6DF01A81-7AA3-43F8-B777-EC52EC50C3DDQ36733712-03EAF2AC-03C7-4953-9FAC-64369CA4EF15Q36746476-B6C508F2-DFA7-4091-B1CC-DFDCA3BF892CQ36914618-5078A5F8-5E9A-4EF5-A882-AC39B9C9F68CQ36924730-CE19A7A0-57F3-43D2-A57A-C200558B8208Q36934614-2591E6B8-C169-425F-8EEA-91A2EFAC25C1Q37012661-4C506437-C662-4A7E-9A36-F4304C45A756Q37033848-A8ACFC64-64C9-4A05-8E54-0EE9BEF0B87BQ37035061-969156F9-D495-4A4D-9584-CD0CED1BC952Q37100836-05331AF8-331E-432C-902F-67D26A50FDF6Q37167931-F7B78980-C05E-44C5-A08A-4AA5BC86BAE7Q37217217-85EC22A0-5452-4E96-8906-75E08C095AD3Q37994369-B89A2CEB-55E7-451C-AFE8-E05F986408C4Q38073714-B4BD0955-EC8F-4635-A973-7F73DD63C682Q38197233-F8C9DD72-E5DB-45C0-A2AC-D98C2C7775E4Q38668630-CDC3FEE4-D304-425F-B94C-4459813CC7DD
P2860
Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Identification and characteriz ...... rvival of motor neuron complex
@ast
Identification and characteriz ...... rvival of motor neuron complex
@en
Identification and characteriz ...... rvival of motor neuron complex
@en-gb
Identification and characteriz ...... rvival of motor neuron complex
@nl
type
label
Identification and characteriz ...... rvival of motor neuron complex
@ast
Identification and characteriz ...... rvival of motor neuron complex
@en
Identification and characteriz ...... rvival of motor neuron complex
@en-gb
Identification and characteriz ...... rvival of motor neuron complex
@nl
prefLabel
Identification and characteriz ...... rvival of motor neuron complex
@ast
Identification and characteriz ...... rvival of motor neuron complex
@en
Identification and characteriz ...... rvival of motor neuron complex
@en-gb
Identification and characteriz ...... rvival of motor neuron complex
@nl
P2093
P2860
P356
P1476
Identification and characteriz ...... rvival of motor neuron complex
@en
P2093
Gideon Dreyfuss
Jennifer Baccon
Matthias Mann
P2860
P304
P356
10.1074/JBC.M203478200
P407
P577
2002-08-30T00:00:00Z