The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseCD74 interacts with APP and suppresses the production of AbetaBRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2BRI2 (ITM2b) inhibits Abeta deposition in vivoIntegrative analysis of the melanoma transcriptomeGene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant miceAPP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functionsDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaGeneration and initial characterization of FDD knock in miceAPP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantModeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomainDanish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsGenetic alterations of the BRI2 gene: familial British and Danish dementias.Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.Yeast two-hybrid, a powerful tool for systems biologyGlycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.Proteomic characterization of a mouse model of familial Danish dementia.β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.Lessons from a Rare Familial Dementia: Amyloid and Beyond.Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.Cerebral amyloidosis: amyloid subunits, mutants and phenotypes.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor proteinCaspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers.APP Receptor? To Be or Not To Be.Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.Increased AβPP processing in familial Danish dementia patients.Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memorySubstrate specificity of gamma-secretase and other intramembrane proteases.BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.Deciphering soluble and membrane protein function using yeast systems (Review).BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease
P2860
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P2860
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@ast
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en-gb
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@nl
type
label
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@ast
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en-gb
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@nl
prefLabel
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@ast
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en-gb
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@nl
P2093
P2860
P356
P1476
The familial dementia BRI2 gen ...... hibits amyloid-beta production
@en
P2093
Blas Frangione
Eileen McGowan
Fiona Pickford
Jorge Ghiso
Luca Giliberto
Luciano D'Adamio
Peter Davies
Shuji Matsuda
Yukiko Matsuda
P2860
P304
P356
10.1074/JBC.C500217200
P407
P577
2005-08-12T00:00:00Z