Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
about
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependenceThe Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeletonHSV-1 and Alzheimer's disease: more than a hypothesis.PAK in Alzheimer disease, Huntington disease and X-linked mental retardationp21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesisSelective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interactionRescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and AβAnalysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks.Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomainThe overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer.Altered processing of amyloid precursor protein in cells undergoing apoptosis.Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity.The small chaperone protein p23 and its cleaved product p19 in cellular stress.The small co-chaperone p23 overexpressing transgenic mouseSignaling through Rho GTPase pathway as viable drug target.Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides.Importance of the caspase cleavage site in amyloid-β protein precursorStructure, biochemistry, and biology of PAK kinases.Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.Novel mediators of amyloid precursor protein signaling.Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.Methods for treating neurological conditions (WO2011159945).Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides.Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34.
P2860
Q21202836-50AB9CC5-CDFF-4C76-89A2-E66CCA8499D1Q26864818-0340D47E-8E80-431C-9962-31D876F0D414Q27692651-623D493C-E1A4-45A3-B16F-9F48993615D6Q28279479-BC42F863-C3F0-4AE3-83BF-55DA226A322FQ28570722-F07D4BD4-E56C-40DD-9DEC-8EC7797C7995Q28574751-CE96BFCC-9052-4D25-8AE9-A8EC242FB5C5Q30512263-6057F972-4AEA-471F-BDC8-56519A2F1889Q33605706-7B37AC13-FC92-4592-8911-60EEABFD2568Q33711589-295D1A47-A303-4CC5-90AD-64BE6527410AQ34328562-2B734C31-C496-4165-8E14-C3670BFF7B10Q34359273-E5FD793F-3AA4-479F-A39E-59730168599FQ34612731-E7242B3D-BEE4-4A25-85AA-95D007120FA7Q35607881-F759AFFA-378A-4CA6-BED1-E68C683CE4A4Q35633977-3141A780-B0D5-409B-9661-4A9DD36017F3Q36582955-B79D57F3-4925-4286-8598-FC8D113E7FA6Q37312315-B99969E3-1E5A-4EB7-81D7-9798C5E069E7Q37727192-41FD3E89-BF53-442E-BD2A-6F61D119CE55Q37789571-8478F0E5-5BAC-443E-8BA2-0A92AAC61078Q38779105-925E3445-8AC0-4757-805B-B89B29C0BF29Q38787153-4FA25D3B-01E1-4C20-BE97-93536BC99E27Q38791517-3DEA093D-80C8-486E-9CC0-66F123FF24B6Q38983075-642E1A1B-C748-45C1-A2F0-D82461357E74Q39762318-C8F72549-EDB2-4EB7-AC4E-34275480FBCCQ45305792-872F9DC1-80C7-44CE-8A1D-F63FC0791D1CQ45340134-8C69451F-C383-4617-8774-E366BA0457BEQ47771892-EA0969BA-98B7-433F-8593-AA77A10CCBC5Q48612127-EE4F6147-E253-441B-90A5-13026ED6369CQ53253609-238ED783-36DB-49A2-B428-5FEFF83CF734
P2860
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Signal transduction in Alzheim ...... nal cleavage of APP at Asp664.
@en
type
label
Signal transduction in Alzheim ...... nal cleavage of APP at Asp664.
@en
prefLabel
Signal transduction in Alzheim ...... nal cleavage of APP at Asp664.
@en
P2093
P2860
P1476
Signal transduction in Alzheim ...... nal cleavage of APP at Asp664.
@en
P2093
Dale E Bredesen
Huidong Tang
Junli Zhang
Surita Banwait
Thuy-Vi V Nguyen
Veronica Galvan
P2860
P304
P356
10.1111/J.1471-4159.2007.05031.X
P407
P577
2007-11-06T00:00:00Z