Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
about
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease miceTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cellsThe Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Vitamin A and Alzheimer's diseaseA mutation in APP protects against Alzheimer’s disease and age-related cognitive declineAlpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brainPAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinIdentification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolismSorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complexAutosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor proteinThe familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta productionBinding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavageLRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseBRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furinNeuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionGeneration of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrinSorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processingFlotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sortingThe potential role of amyloid beta in the pathogenesis of age-related macular degeneration.The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifBiological markers of amyloid beta-related mechanisms in Alzheimer's diseaseCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsDifferential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cellsProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseHuman aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor proteinSignaling effect of amyloid-beta(42) on the processing of AbetaPPAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinThe amyloid precursor protein: beyond amyloidModulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHMice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease ModelsStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsImmunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges
P2860
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P2860
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@ast
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en-gb
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@nl
type
label
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@ast
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en-gb
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@nl
prefLabel
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@ast
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en-gb
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@nl
P2093
P921
P3181
P1433
P1476
Beta-secretase cleavage of Alz ...... embrane aspartic protease BACE
@en
P2093
B D Bennett
D B Teplow
E A Mendiaz
P304
P3181
P356
10.1126/SCIENCE.286.5440.735
P407
P577
1999-10-22T00:00:00Z