Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism - Test2 - elhamkhani - TriplyDB

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE Ubiquitin is a novel substrate for human insulin-degrading enzyme A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro Molecular basis for the thiol sensitivity of insulin-degrading enzyme Alzheimer's disease--a panorama glimpse Identification of the allosteric regulatory site of insulysin Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme Crystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut Case Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 Anion Activation Site of Insulin-degrading Enzyme Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis Stepwise organization of the β-structure identifies key regions essential for the propagation and cytotoxicity of insulin amyloid fibrils.The conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length.Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.Cloning, expression and characterization of insulin-degrading enzyme from tomato (Solanum lycopersicum).The pyrroloquinoline quinone biosynthesis pathway revisited: a structural approach.Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1 Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation.Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification.Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease.Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides.

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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name

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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type

label

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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Marsha Rich Rosner

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Yuequan Shen

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P2860

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study

X-ray analysis of glucagon and its relationship to receptor binding

Conformation of glucagon in a lipid-water interphase by 1H nuclear magnetic resonance

Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

Coot: model-building tools for molecular graphics

Shape complementarity at protein/protein interfaces

Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection.

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870-4

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1810087

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10.1038/NATURE05143

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7113

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443

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Andrzej Joachimiak

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2006-10-19T00:00:00Z

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6745041

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1029942463

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Insulin degrading enzyme

insulin binding

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3366509

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