Molecular basis for the thiol sensitivity of insulin-degrading enzyme - Test2 - elhamkhani - TriplyDB

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

http://www.wikidata.org/entity/Q24657471

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Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation.Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation Redox regulation of insulin degradation by insulin-degrading enzyme.Nontoxic antimicrobials that evade drug resistance.Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation.The AbetaCs of Abeta-cleaving proteases.Proteolytic degradation of amyloid β-protein.Potential efficacy of Lactobacillus casei IBRC_M10711 on expression and activity of insulin degrading enzyme but not insulin degradation.Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease.Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin.C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells Reactive cysteine in the active-site motif of Bacteroides thetaiotaomicron dipeptidyl peptidase III is a regulatory residue for enzyme activity.Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display.Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.Inhibition of Insulin Degrading Enzyme and Insulin Degradation by UV-Killed Lactobacillus acidophilus.

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P2860

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

http://www.wikidata.org/entity/Q24657471

description

2008 nî lūn-bûn

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2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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type

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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prefLabel

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

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PNAS.0801261105

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Proceedings of the National Academy of Sciences of the United States of America

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Molecular basis for the thiol sensitivity of insulin-degrading enzyme

@en

P2093

Dennis J Selkoe

http://www.w3.org/2001/XMLSchema#string

Lael Reinstatler

http://www.w3.org/2001/XMLSchema#string

Lilin Li

http://www.w3.org/2001/XMLSchema#string

Malcolm A Leissring

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Marie Neant-Fery

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Rubén D Garcia-Ordoñez

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Todd P Logan

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P2860

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

The insulysin (insulin degrading enzyme) enigma

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families

A genome-wide association study identifies novel risk loci for type 2 diabetes

Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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9582-7

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scholarly article

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10.1073/PNAS.0801261105

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105

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2008-07-15T00:00:00Z

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