Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †
about
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.Ubiquitin is a novel substrate for human insulin-degrading enzymeIdentification of the allosteric regulatory site of insulysinMolecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading EnzymeMolecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading EnzymeDesigned Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of InsulinStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzymeAnti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormonesSmall-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screeningStructure based discovery of small molecules to regulate the activity of human insulin degrading enzymeA monomeric variant of insulin degrading enzyme (IDE) loses its regulatory propertiesProtective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation.Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a D-galactose-induced mouse model.Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activationInsulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.Redox regulation of insulin degradation by insulin-degrading enzyme.Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanismStructures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin-degrading enzyme.Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.Aberrant protein s-nitrosylation in neurodegenerative diseases.Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications.Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes MellitusCopper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin.Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin.Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme.Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.β-Amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2).Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?Mechanisms of peptide hydrolysis by aspartyl and metalloproteases.Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease
P2860
Q24304041-EF8F2A20-C664-4689-9A00-6EEFA6A0F9F8Q24321299-68E0C352-52EA-4BFE-B3B4-EF066204E16DQ27335211-B4604558-494A-44C0-9E39-A005430B239CQ27654373-9F9A449C-72C9-414E-ABEF-0953422B0186Q27658095-5BFEE6CC-EFA0-4265-BD97-D6465B51A28FQ27661904-97A8BAD3-0B0B-41E9-82CD-44EEDE21C8C5Q27667473-E32E24EA-18DB-4E3D-91EA-89E8662301D1Q27679412-6A3B3F49-4107-4A4F-8C65-DB5C5F2D8B47Q27683870-683371D7-EC36-439B-AFE6-06BDAA66E0BFQ28475342-21B78E27-85C3-4B40-9DCB-C1AB0A9BBF7FQ28480725-C8E0AB55-CE85-4622-992C-EC3999A0795FQ33543086-FDAC35B3-2973-4CF4-AEBB-124147C15833Q33553407-1A379CF3-6518-4F40-8DAE-CA9203991F07Q34116082-129A928E-707E-4A75-8CB2-120CFA6A6D6AQ34450404-8EABD8AE-472B-4FE3-AB63-C4CA93ADCE75Q34575644-AD19793D-4ACF-4DA9-B5B7-B87486688E0DQ34712680-CFE789EE-DD07-4CC7-9FC6-7D2738FC0962Q34799851-3D964020-11D2-470C-A3E4-C3747B11460FQ35164366-81BC909A-0362-4494-8C62-D4B67A0FCB51Q35178620-718E005E-1403-4C0A-BF54-68689F6D69E8Q35953055-26471027-5A86-492E-A285-52083384E4E6Q37415871-247A72F9-9E21-4E15-B223-07A791C16DC0Q38110376-90E5E9D7-A90B-4524-8F01-F58EB0BE0245Q38601445-C00B13ED-AADB-4EC8-8951-2D7D0C66FF14Q38664408-30E35BC1-5C65-490A-90B9-434631E093BBQ38763060-2A015743-0E3C-48D6-8C19-86883069693BQ39436794-47C53C19-FFD8-457E-8DEF-48BAA87130C2Q41788885-027C5B6B-0C2C-499F-B1FC-070B19948DEEQ42409261-7745D101-63B2-4C00-8676-13E46A310934Q45918584-4D6D225C-8DAE-4941-8B11-84773EDB0549Q47643834-B2E86BD2-972C-489F-BA64-A2E7FDBB01B3Q50932512-7BE1496A-3E23-405C-BA0D-EBFC61C8EA9BQ51423259-EF52CB01-A85D-45DE-B3C0-A94FF8E82843Q51608953-F7744695-7642-4D67-8D75-3C1925241B18Q52622522-94B9B1BE-4936-4CBC-88EC-22DCED44D7C9Q58553049-40C8A291-DE67-4713-8456-CCC1A423B27D
P2860
Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@ast
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@en
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@nl
type
label
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@ast
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@en
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@nl
prefLabel
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@ast
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@en
Molecular Bases for the Recogn ...... man Insulin-Degrading Enzyme †
@nl
P2093
P2860
P356
P1433
P1476
Molecular bases for the recogn ...... human insulin-degrading enzyme
@en
P2093
Enrico Malito
Julie L Tsay
Luis A Ralat
Marika Manolopoulou
P2860
P304
12822-12834
P356
10.1021/BI801192H
P407
P577
2008-12-01T00:00:00Z