Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
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Conformational coupling across the plasma membrane in activation of the EGF receptorTen things you should know about protein kinases: IUPHAR Review 14Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1Assessing the range of kinase autoinhibition mechanisms in the insulin receptor familyAffinity-Based Probes Based on Type II Kinase InhibitorsThe Structure of Arabidopsis thaliana OST1 Provides Insights into the Kinase Regulation Mechanism in Response to Osmotic StressActive site profiling reveals coupling between domains in SRC-family kinasesThe CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508Sequence Determinants of a Specific Inactive Protein Kinase ConformationStructural basis of AMPK regulation by small molecule activatorsStructural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6Structural snapshots along the reaction pathway ofYersinia pestisRipA, a putative butyryl-CoA transferaseConformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein KinasesChloride Sensing by WNK1 Involves Inhibition of AutophosphorylationMolecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformationCrystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activitySmall-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based DockingActivating HER2 mutations in HER2 gene amplification negative breast cancerIn vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancerDynamics-Driven Allostery in Protein KinasesDeciphering the structural basis of eukaryotic protein kinase regulationMagnetic nanoparticles as mediators of ligand-free activation of EGFR signalingA unified view of "how allostery works"The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionCo-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailDivergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Structural dynamic analysis of apo and ATP-bound IRAK4 kinaseTargeting substrate-site in Jak2 kinase prevents emergence of genetic resistanceConformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesNormal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implicationsPredicting inactive conformations of protein kinases using active structures: conformational selection of type-II inhibitors.Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering.Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases
P2860
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P2860
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Catalytic control in the EGF r ...... kinase regulatory mechanisms.
@ast
Catalytic control in the EGF r ...... kinase regulatory mechanisms.
@en
type
label
Catalytic control in the EGF r ...... kinase regulatory mechanisms.
@ast
Catalytic control in the EGF r ...... kinase regulatory mechanisms.
@en
prefLabel
Catalytic control in the EGF r ...... kinase regulatory mechanisms.
@ast
Catalytic control in the EGF r ...... kinase regulatory mechanisms.
@en
P2093
P2860
P1433
P1476
Catalytic control in the EGF r ...... l kinase regulatory mechanisms
@en
P2093
John Kuriyan
Natalia Jura
Nicholas F Endres
Thomas Schindler
Xuewu Zhang
P2860
P356
10.1016/J.MOLCEL.2011.03.004
P577
2011-04-01T00:00:00Z