C-terminal phosphorylation controls the stability and function of p27kip1
about
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategyRSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasionRole of T198 modification in the regulation of p27(Kip1) protein stability and functionEndoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα productionCdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylationThe energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosisp27(Kip1) controls cytokinesis via the regulation of citron kinase activation.MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinomaSiah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer.p27kip1: a target for tumor therapies?Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitorsCytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress.NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation.Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescenceDFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.Molecular mechanisms underlying progesterone-enhanced breast cancer cell migration.Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesisp27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysisSUMOylation regulates p27Kip1 stability and localization in response to TGFβ.Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest.AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability.Transcriptional downregulation of p27KIP1 through regulation of E2F function during LMP1-mediated transformation.Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549.Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G.The missing link?: Arabidopsis SPCH is a MAPK specificity factor that controls entry into the stomatal lineage.General strategy for understanding intracellular molecular interaction cascades that elicit stimulus-invoked biological processes
P2860
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P2860
C-terminal phosphorylation controls the stability and function of p27kip1
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
C-terminal phosphorylation controls the stability and function of p27kip1
@ast
C-terminal phosphorylation controls the stability and function of p27kip1
@en
C-terminal phosphorylation controls the stability and function of p27kip1
@en-gb
C-terminal phosphorylation controls the stability and function of p27kip1
@nl
type
label
C-terminal phosphorylation controls the stability and function of p27kip1
@ast
C-terminal phosphorylation controls the stability and function of p27kip1
@en
C-terminal phosphorylation controls the stability and function of p27kip1
@en-gb
C-terminal phosphorylation controls the stability and function of p27kip1
@nl
prefLabel
C-terminal phosphorylation controls the stability and function of p27kip1
@ast
C-terminal phosphorylation controls the stability and function of p27kip1
@en
C-terminal phosphorylation controls the stability and function of p27kip1
@en-gb
C-terminal phosphorylation controls the stability and function of p27kip1
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
C-terminal phosphorylation controls the stability and function of p27kip1
@en
P2093
Holly A Sundberg
Irina Nickeleit
Michael P Manns
Nisar P Malek
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601388
P407
P577
2006-10-19T00:00:00Z