The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function
about
Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individualsThe human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and functionCHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injuryRethinking inflammation: neural circuits in the regulation of immunity.Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived NeuronsNicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.Evidence for gamma and beta sensory gating deficits as translational endophenotypes for schizophrenia.Evolution of genetic and genomic features unique to the human lineage.The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7.Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorderAlpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia.A Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression.The human clinical phenotypes of altered CHRNA7 copy numberAnalysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family StudyAssociation between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gatingOrdered subset analysis of copy number variation association with age at onset of Alzheimer's disease.Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorderAssociation study of the 2-bp deletion polymorphism in exon 6 of the CHRFAM7A gene with idiopathic generalized epilepsy.Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker15q13.3 duplication in two patients with childhood-onset schizophrenia.Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.Ohnologs are overrepresented in pathogenic copy number mutations.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.Nicotinic acetylcholine receptors in human genetic disease.Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation.CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPSIncreased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis.Usefulness of α7 nicotinic receptor messenger RNA levels in peripheral blood mononuclear cells as a marker for cholinergic antiinflammatory pathway activity in septic patients: results of a pilot study.Up-regulation of the human-specific CHRFAM7A gene in inflammatory bowel disease.Cholinergic modulation of the immune system presents new approaches for treating inflammation.Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T LeukemiaPromoter methylation and tissue-specific transcription of the α7 nicotinic receptor gene, CHRNA7.Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo.Expression and Function of the Cholinergic System in Immune Cells.CNTN6 copy number variations in 14 patients: a possible candidate gene for neurodevelopmental and neuropsychiatric disordersFunctional Consequences of CHRNA7 Copy-Number Alterations in Induced Pluripotent Stem Cells and Neural Progenitor Cells.Neuronal and extraneuronal nicotinic acetylcholine receptors.Microduplication of 15q13.3 and Xq21.31 in a family with Tourette syndrome and comorbidities.Is Chromosome 15q13.3 Duplication Involving CHRNA7 Associated With Oral Clefts?
P2860
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P2860
The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function
description
2011 nî lūn-bûn
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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
@zh-tw
2011年论文
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name
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@ast
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en-gb
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@nl
type
label
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@ast
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en-gb
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@nl
prefLabel
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@ast
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en-gb
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@nl
P2093
P2860
P921
P3181
P1476
The chimeric gene CHRFAM7A, a ...... regulator of α7*nAChR function
@en
P2093
Daniel Bertrand
Estele Neveu
Michael Lee
Ralph Berger
Sharon Graw
Sherry Leonard
Tanguy Araud
P2860
P304
P3181
P356
10.1016/J.BCP.2011.06.018
P407
P577
2011-10-15T00:00:00Z