The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
about
Identification and characterization of GRIM-1, a cell-death-associated gene productThe import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chainGRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex ITyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytesStable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cellsMitochondrial Stat3, the Need for Design ThinkingPivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved IssuesMitochondrial STAT3 and reactive oxygen species: A fulcrum of adipogenesis?Whole-genome methylation analysis of benign and malignant colorectal tumoursSTAT3 as a therapeutic target in head and neck cancerMitochondrial Metabolism in Aging HeartDifferentially expressed proteins in malignant and benign adrenocortical tumorsThe Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gammaTranscriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cellsMitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol.Mutation in NDUFA13/GRIM19 leads to early onset hypotonia, dyskinesia and sensorial deficiencies, and mitochondrial complex I instability.DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosisGRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activityGRIM-19 Expression and Function in Human Gliomas.Cytokine-induced tumor suppressors: a GRIM storyDown-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses.Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potentialDownregulation of gene expression and activity of GRIM-19 affects mouse oocyte viability, maturation, embryo development and implantationSignal transducers and activators of transcription: insights into the molecular basis of oral cancer.Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashionTumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels.Grim19 Attenuates DSS Induced Colitis in an Animal Model.GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis.Opposing actions of STAT-1 and STAT-3.Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.Crosstalk between signaling pathways of adrenoreceptors and signal transducers and activators of transcription 3 (STAT3) in heart.STAT transcription in the ischemic heart.The IFN-beta and retinoic acid-induced cell death regulator GRIM-19 is upregulated during focal cerebral ischemia.GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation.GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring.
P2860
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P2860
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The cell death regulator GRIM- ...... d activator of transcription 3
@ast
The cell death regulator GRIM- ...... d activator of transcription 3
@en
The cell death regulator GRIM- ...... d activator of transcription 3
@en-gb
The cell death regulator GRIM- ...... d activator of transcription 3
@nl
type
label
The cell death regulator GRIM- ...... d activator of transcription 3
@ast
The cell death regulator GRIM- ...... d activator of transcription 3
@en
The cell death regulator GRIM- ...... d activator of transcription 3
@en-gb
The cell death regulator GRIM- ...... d activator of transcription 3
@nl
prefLabel
The cell death regulator GRIM- ...... d activator of transcription 3
@ast
The cell death regulator GRIM- ...... d activator of transcription 3
@en
The cell death regulator GRIM- ...... d activator of transcription 3
@en-gb
The cell death regulator GRIM- ...... d activator of transcription 3
@nl
P2093
P2860
P3181
P356
P1476
The cell death regulator GRIM- ...... d activator of transcription 3
@en
P2093
Dhananjaya V Kalvakolanu
George R Stark
Jacqueline F Bromberg
Jinbo Yang
Sanjit K Roy
Silvia Tininini
Valeria Poli
P2860
P304
P3181
P356
10.1073/PNAS.1633516100
P407
P577
2003-08-05T00:00:00Z