The E3 ligase TRAF6 regulates Akt ubiquitination and activation
about
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activityAkt is negatively regulated by the MULAN E3 ligaseActivation of interferon regulatory factor 5 by site specific phosphorylationPharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progressionThe CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradationSCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathwayThe Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesisEmerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer developmentSkp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescenceTherapeutic Implications of Targeting AKT Signaling in MelanomaUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responseActivated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitroBreaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression.Deconstructing innate immune signaling in myelodysplastic syndromesRegulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and agingPhosphorylation of Akt at the C-terminal tail triggers Akt activationRegulation of cardiac autophagy by insulin-like growth factor 1Posttranslational regulation of Akt in human cancerSPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delaminationThe ubiquitin system: a critical regulator of innate immunity and pathogen-host interactionsA proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory rolesKinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwayProtein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylationUbiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxiaThe conformational control inhibitor of tyrosine kinases DCC-2036 is effective for imatinib-resistant cells expressing T674I FIP1L1-PDGFRαCurcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt DegradationZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylationToll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisThe tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and suv ubiquitin E2 variant positively regulate plant immunityPhysical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinaseRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesDeactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNAGenomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in miceCKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activationβ-Elemene Selectively Inhibits the Proliferation of Glioma Stem-Like Cells Through the Downregulation of Notch1.A novel gene, MdSSK1, as a component of the SCF complex rather than MdSBP1 can mediate the ubiquitination of S-RNase in appleB-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells
P2860
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P2860
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@ast
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en-gb
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@nl
type
label
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@ast
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en-gb
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@nl
prefLabel
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@ast
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en-gb
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@nl
P2093
P2860
P921
P3181
P356
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P1476
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
@en
P2093
Alejandro D Campos
Betty Lamothe
Brian C Grabiner
Bryant G Darnay
Chia-Hsin Chan
Hui-Kuan Lin
Szu-Wei Lee
Wei-Lei Yang
P2860
P304
P3181
P356
10.1126/SCIENCE.1175065
P407
P577
2009-08-28T00:00:00Z