A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activationProfiling critical cancer gene mutations in clinical tumor samplesSecond AKT: the rise of SGK in cancer signallingShepherding AKT and androgen receptor by Ack1 tyrosine kinaseShould individual PI3 kinase isoforms be targeted in cancer?The E3 ligase TRAF6 regulates Akt ubiquitination and activationMOZ increases p53 acetylation and premature senescence through its complex formation with PMLPI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancerA mosaic activating mutation in AKT1 associated with the Proteus syndromeAnalysis of the genome to personalize therapy for melanomaTamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selectionA systematic screen for protein-lipid interactions in Saccharomyces cerevisiaeEmerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer developmentPHLiPPing the switch on Akt and protein kinase C signalingTherapeutic Implications of Targeting AKT Signaling in MelanomaThe PI3K pathway as drug target in human cancerUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responseMosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CATargeting the PI3K signaling pathway in cancerSomatic mutations affect key pathways in lung adenocarcinomaDepletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoformsMechanisms Behind the Resistance to Trastuzumab in HER2-Amplified Breast Cancer and Strategies to Overcome ItTargeting RTK Signaling Pathways in CancerPI3K and AKT: Unfaithful Partners in CancerThe PI3K/AKT Pathway and Renal Cell CarcinomaPI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical applicationSomatic mosaicism in the human genomeTargeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignanciesDiverse mechanisms of AKT pathway activation in human malignancyPhosphatidylinositol 3-kinase and antiestrogen resistance in breast cancerRegulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and agingAutophagy in malignant transformation and cancer progressionTargeted therapies in development for non-small cell lung cancerPosttranslational regulation of Akt in human cancerDual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugsCrystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionAn ATP-site on-off switch that restricts phosphatase accessibility of AktOvergrowth Syndromes.Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingPIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.
P2860
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P2860
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@ast
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@en
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@nl
type
label
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@ast
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@en
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@nl
prefLabel
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@ast
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@en
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@nl
P2093
P3181
P356
P1433
P1476
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
@en
P2093
Andrew L Faber
Candice Horn
Christiane M Robbins
Douglas J Zeckner
Galen Hostetter
Gregory P Donoho
James E Thomas
Jeffrey Touchman
P2860
P2888
P304
P3181
P356
10.1038/NATURE05933
P407
P577
2007-07-26T00:00:00Z
P5875
P6179
1023428666