The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis - Test2 - elhamkhani - TriplyDB

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

http://www.wikidata.org/entity/Q24613186

about

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response Cullin-RING ligases in regulation of autophagy Drugging the undruggables: exploring the ubiquitin system for drug development The sweet trap in tumors: aerobic glycolysis and potential targets for therapy The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Mediator kinase module and human tumorigenesis Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging Signaling cross-talk in the resistance to HER family receptor targeted therapy Posttranslational regulation of Akt in human cancer Structural insights into the TRIM family of ubiquitin E3 ligases Histone methylation modifiers in cellular signaling pathways Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent The conformational control inhibitor of tyrosine kinases DCC-2036 is effective for imatinib-resistant cells expressing T674I FIP1L1-PDGFRα NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Assessing the clinical utility of genomic expression data across human cancers.Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma.Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.Roles of F-box proteins in cancer Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2).Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination.SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice.Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications.Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis.Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma.The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload.

P2860

Q24314416-C8D9A22E-4903-4B54-8F64-F0E1E56266BD Q24632317-647C5006-AD16-4D99-A9FA-B7C8AE2C421B Q26746956-DEB6663C-5594-43E9-8165-2600226A146C Q26752823-72A7E9B5-AA6B-4C7A-AAC0-6DAB09873508 Q26766079-5073F179-DB8E-42C3-814D-2A8AF9500803 Q26782159-618E4EA8-D837-4E7E-B1DC-BDE14E4DF655 Q26800203-DD977DED-2B24-4AC4-AE8C-AF39A2143751 Q26998765-1B4C1E0A-ADFB-4944-A6DA-6C613941F2B8 Q27027778-F993154D-6E11-4286-85BC-BAE0B0F665DB Q27027815-3459D548-D68E-4F6B-9372-C7A751617487 Q27683218-742E4E40-BD9D-448D-82DC-D44361051CEC Q28082123-5D0EA1BD-F447-4D53-B804-C9209984D871 Q28484382-380ADECC-0B59-4D3F-B666-A8265F397000 Q28535951-AC208668-F777-405C-B943-7CEB04E1FED3 Q30276974-3F39E0F7-93F8-4392-BC23-79C3D0A398D1 Q30278581-124E6E28-36EA-45D2-89D3-200CFCBAE011 Q31109151-DBC99FC0-648B-40D7-A615-3F7056C03952 Q33608923-8A4650A1-95E6-4914-99D6-7C3779571AFE Q33714257-C8810412-06D6-4626-B882-A0891F0E0892 Q33737298-0ACAF9F4-7CE7-48D6-A2F0-AF4888771EB2 Q34117589-E009D3A4-0F31-450A-86CD-946BA95D75D9 Q34169595-11EBBFC0-A39B-4215-BBA4-D0FF62722E2F Q34221801-DA04566B-AA77-49DA-B78B-673550F0882E Q34452014-3C4F4893-24F3-45EE-91A5-2231DCE6AA23 Q34541027-C4EC0DC1-FE54-4799-A1C1-7104E1EC69A3 Q34554617-326E8952-239B-4CAF-BFFB-5261D9E5A866 Q34629544-03BADC23-6CAB-4642-8DE4-96ABB023D914 Q34746718-D925175E-F7B1-4537-B4E3-6DFF57B57F14 Q34770075-5E0026A8-627C-49C3-A176-D9F0C9138E3A Q35012352-A6E18E60-EF47-4AF0-AE62-3BCD81748C0A Q35048859-19248DD3-2051-4EBF-AB77-225464412363 Q35158033-FEE35FD4-34A4-4131-ADD4-1619CA01076D Q35176138-85BFA217-73FD-4843-A579-97AE18D54E3C Q35273519-20A114C3-FBEA-48CC-8D7A-7C61A24E019F Q35380380-0CFA5F01-5ABB-4E34-BCBF-0FF4298294BA Q35686894-F511F86F-0DE8-4724-8125-DDDFC0A6860E Q35845610-8975E1C7-780A-4DFE-B739-395638899E51 Q35848294-9B39F8D9-602C-412D-820C-13DFB7521445 Q36146344-4B845C08-5820-4E1A-907B-5FF98AF9069D Q36227198-4B080882-71D3-45DE-9B9E-2DBB3DC86E6D

P2860

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

http://www.wikidata.org/entity/Q24613186

description

2012 nî lūn-bûn

@nan

2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@ast

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@en

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@nl

type

label

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@ast

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@en

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@nl

prefLabel

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@ast

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@en

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@nl

P1433

Q24613186-608494BB-CCA7-419E-A0EF-8E5485419356

P1476

Q24613186-3E65E43B-9844-4C53-A0D8-F9FF356EFBF6

P2093

Q24613186-0AC95642-1C63-48B6-9AD7-9974ABCD31AE

Q24613186-1413C891-7D3D-4922-AB76-9F802C131E16

Q24613186-230893E2-54A5-46EF-A2A7-E1D152CB3BE0

Q24613186-2DA7CC93-25CF-4A38-BD0C-2C5D44039D6D

Q24613186-39641BB1-6A12-44D8-8FDE-40B8BA8B8D40

Q24613186-63894E49-30B9-4089-AA41-4ADFA5043972

Q24613186-73286BD1-4954-4FB8-B46D-B7B601E63352

Q24613186-8036C835-CA18-4FFF-AF7A-29FD24AE905F

Q24613186-8A3369C1-57E2-4A6C-9CAF-9C646E1F6D12

Q24613186-8F541CBF-9E67-4339-BA3C-C601652DF929

P2860

Q24613186-051104BE-BABD-477C-87F3-4BAF392499F3

Q24613186-069D729C-8766-4D7E-8A22-D456F58DA8F2

Q24613186-08A6CCED-CD63-4DD7-8387-97029B0CE387

Q24613186-0E922932-8B7D-4B6A-8AA3-3A753C2B063C

Q24613186-10B81DEE-2B00-4B4C-A86D-1DA6C3E3D6EC

Q24613186-1F17F02E-C568-46F5-BBC6-479FF20C886A

Q24613186-1FA32147-3127-4384-A012-8F10B542FC1E

Q24613186-26A82F4E-8059-4B34-839B-224AD423A339

Q24613186-2AF3A283-9641-4993-8465-0077B0E22DD9

Q24613186-2E1C04EB-B7F0-4DE8-BFE4-011EBBC85C65

P304

Q24613186-CA307E86-9108-41FD-90B2-11A2132A9039

P31

Q24613186-C98F06C4-69BD-425D-BF93-3B595912123C

P3181

Q24613186-5DCEDF11-53FD-4764-8112-E1B357DC4D12

P356

Q24613186-13F2A285-CAAA-491E-977A-DEAE22EB9CD6

P407

Q24613186-E4DC4F3F-5954-4827-8B0B-A0A3A8F61905

P433

Q24613186-8C560FE6-8B3A-4265-922F-96A6CBD0BB0B

P478

Q24613186-FA2195A9-FE5B-4656-A26E-569C146ADB7C

P50

Q24613186-D0399955-E5B6-4DEE-9893-A89459485BE7

P577

Q24613186-3B2D0432-3115-4891-BD5D-FE2EE250B30D

P5875

Q24613186-17BB9087-495E-4F69-95A1-E2086455EA01

P698

Q24613186-C8A65417-A222-46F6-81A7-D71F4C25CD24

P921

Q24613186-7A0DE08E-18BB-4B76-BFB1-DE932F4EB6B4

P932

Q24613186-C7083C32-D4E0-45A6-AE8B-CAEC0DE4FE40

P3181

P356

J.CELL.2012.02.065

P1433

P1476

The Skp2-SCF E3 ligase regulat ...... sensitivity, and tumorigenesis

@en

P2093

Chien-Feng Li

http://www.w3.org/2001/XMLSchema#string

Dihua Yu

http://www.w3.org/2001/XMLSchema#string

Dos Sarbassov

http://www.w3.org/2001/XMLSchema#string

Hsuan-Ying Huang

http://www.w3.org/2001/XMLSchema#string

Hui-Kuan Lin

http://www.w3.org/2001/XMLSchema#string

John D Hazle

http://www.w3.org/2001/XMLSchema#string

Keiichi I Nakayama

http://www.w3.org/2001/XMLSchema#string

Kelvin K C Tsai

http://www.w3.org/2001/XMLSchema#string

Leo G Flores

http://www.w3.org/2001/XMLSchema#string

Mien-Chie Hung

http://www.w3.org/2001/XMLSchema#string

P2860

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

Direct activation of protein kinases by unanchored polyubiquitin chains

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

P304

1098-1111

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

868563

http://www.w3.org/2001/XMLSchema#string

P356

10.1016/J.CELL.2012.02.065

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

149

http://www.w3.org/2001/XMLSchema#string

P50

P577

2012-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

225045575

http://www.w3.org/2001/XMLSchema#string

P698

22632973

http://www.w3.org/2001/XMLSchema#string

P921

protein ubiquitination

P932

3586339

http://www.w3.org/2001/XMLSchema#string